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Journal of Health Sciences and Medicine

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Original Article
The usefulness of arylesterase in predicting contrast-induced nephropathy in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention
Abstract
Aims: Oxidative stress is one of the causes of contrast-induced nephropathy (CIN). Paraoxonase1 (PON1), is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase (AREase) activity. To explore relationship between AREase activity and CIN development. Material and
Methods: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN (+) and CIN (-). The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis.
Results: Out of the study patients, 13 were CIN (+) and 45 were CIN (-). AREase activity was found to be statistically significantly lower in the CIN (+) group (875 U/L vs 819 U/L, p= 0.004). In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level <824.1 U/L predicted the development of CIN with 61.5% sensitivity and 86.7% specificity (AUC= 0.768, 95% CI= 0.638-0.868, p=0.001).
Conclusion: AREase level is an independent risk factor for the development of CIN and can be used for the prediction of CIN development.

Keywords : Acute myocardial infarction/STEMI, angiography, coronary, coronary artery disease, percutaneous coronary intervention (PCI), renal disease, acute

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1. Haq MFU, Yip CS, Arora P. The conundrum of contrast-inducedacute kidney injury. J Thorac Dis 2020; 12: 1721-7.
2. Mehran R, Dangas GD, Weisbord SD. Contrast-Associated AcuteKidney Injury. N Engl J Med 2019; 380: 2146-55.
3. McCullough PA, Choi JP, Feghali GA, et al. Contrast-InducedAcute Kidney Injury. J Am Coll Cardiol 2016; 68: 1465-73.
4. Kusirisin P, Chattipakorn SC, Chattipakorn N. Contrast-inducednephropathy and oxidative stress: mechanistic insights for betterinterventional approaches. J Transl Med 2020; 18: 400.
5. Keeley EC, Boura JA, Grines CL. Primary angioplasty versusintravenous thrombolytic therapy for acute myocardial infarction:a quantitative review of 23 randomised trials. Lancet 2003; 361:13-20.
6. Ako J, Morino Y, Okuizumi K, Usami M, Nakamura M. Japanesepostmarketing surveillance of clopidogrel in patients with non-ST-segment elevation acute coronary syndrome, stable angina,old myocardial infarction, and ST-segment elevation myocardialinfarction after percutaneous coronary intervention in a real-lifesetting: the final report (J-PLACE Final). Cardiovasc Interv Ther2016; 31: 101-13.
7. Authors/Task Force members, Windecker S, Kolh P, et al. 2014ESC/EACTS Guidelines on myocardial revascularization: TheTask Force on Myocardial Revascularization of the EuropeanSociety of Cardiology (ESC) and the European Association forCardio-Thoracic Surgery (EACTS)Developed with the specialcontribution of the European Association of PercutaneousCardiovascular Interventions (EAPCI). Eur Heart J 2014; 35:2541-619.
8. Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-ParmoSL, La Du BN. Paraoxonase inhibits high-density lipoproteinoxidation and preserves its functions. A possible peroxidative rolefor paraoxonase. J Clin Invest 1998; 101: 1581-90.
9. Ak&ccedil;ay AB, Camsarı A, Ozcan T, et al. The relationship betweenparaoxonase-1 activity and coronary artery disease in patientswith metabolic syndrome. Turk Kardiyol Dern Ars 2011; 39: 371-7.
10. Bhat, M.A., G. Gandhi. Elevated oxidative DNA damage inpatients with coronary artery disease and its association withoxidative stress biomarkers. Acta Cardiol 2019; 74: 153-60.
11. Mehran, R., E. Nikolsky. Contrast-induced nephropathy:definition, epidemiology, and patients at risk. Kidney Int Suppl2006; 100: S11-5.
12. Haagen, L., A. Brock. A new automated method for phenotypingarylesterase (EC 3.1.1.2) based upon inhibition of enzymatichydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J ClinChem Clin Biochem 1992; 30: 391-5.
13. La Du, B.N. The human serum paraoxonase/arylesterasepolymorphism. Am J Hum Genet 1988; 43: 227-9.
14. Tang WH, Hartiala J, Fan Y, et al. Clinical and genetic association ofserum paraoxonase and arylesterase activities with cardiovascularrisk. Arterioscler Thromb Vasc Biol 2012; 32: 2803-12.
15. Moradi H, Pahl MV, Elahimehr R, Vaziri ND. Impairedantioxidant activity of high-density lipoprotein in chronic kidneydisease. Transl Res 2009; 153: 77-85.
16. B&ouml;rek&ccedil;i A, G&uuml;r M, T&uuml;rkoğlu C, et al. Oxidative stress andparaoxonase 1 activity predict contrast-induced nephropathyin patients with ST-segment elevation myocardial infarctionundergoing primary percutaneous coronary intervention.Angiology 2015; 66: 339-45.
17. Serdar Z, Aslan K, Dirican M, Sarand&ouml;l E, Yeşilbursa D, SerdarA. Lipid and protein oxidation and antioxidant status in patientswith angiographically proven coronary artery disease. ClinBiochem 2006; 39: 794-803.
18. He H, Chen XR, Chen YQ, Niu TS, Liao YM. Prevalence andpredictors of contrast-induced nephropathy (CIN) in patientswith ST-segment elevation myocardial infarction (STEMI)undergoing percutaneous coronary intervention (PCI): a meta-analysis. J Interv Cardiol 2019; 2019: 2750173.
19. Cholesterol Treatment Trialists&#39; (CTT) Collaboration, Fulcher J,O&#39;Connell R, et al. Efficacy and safety of LDL-lowering therapyamong men and women: meta-analysis of individual data from174,000 participants in 27 randomised trials. Lancet 2015; 385:1397-405.
20. Reddy VS, Bui QT, Jacobs JR, et al. Relationship between serumlow-density lipoprotein cholesterol and in-hospital mortalityfollowing acute myocardial infarction (the lipid paradox). Am JCardiol 2015; 115: 557-62.
21. Dong S, Ji W, Zeng S, et al. Admission low-density lipoproteincholesterol stratified by circulating CD14++CD16+ monocytesand risk for recurrent cardiovascular events following ST elevationmyocardial infarction: lipid paradox revised. J Cardiovasc TranslRes 2020; 13: 916-27.
22. Duong MH, MacKenzie TA, Malenka DJ. N-acetylcysteineprophylaxis significantly reduces the risk of radiocontrast-induced nephropathy: comprehensive meta-analysis. CatheterCardiovasc Interv 2005; 64: 471-9.
23. Nallamothu BK, Shojania KG, Saint S, et al. Is acetylcysteineeffective in preventing contrast-related nephropathy? A meta-analysis. Am J Med 2004; 117: 938-47.
24. Spargias K, Alexopoulos E, Kyrzopoulos S, et al. Ascorbic acidprevents contrast-mediated nephropathy in patients with renaldysfunction undergoing coronary angiography or intervention.Circulation 2004; 110: 2837-42.
25. Tasanarong A, Vohakiat A, Hutayanon P, Piyayotai D. New strategyof alpha- and gamma-tocopherol to prevent contrast-inducedacute kidney injury in chronic kidney disease patients undergoingelective coronary procedures. Nephrol Dial Transplant 2013; 28:337-44.
26. Farmer, JA. Pleiotropic effects of statins. Curr Atheroscler Rep2000; 2: 208-17.
Article available in :
Volume 6, Issue 2, 2023
Page : 244-249
https://doi.org/10.32322/jhsm.1221793
Article Information
Received : 20 Ara 2022
Accepted : 14 Oca 2023
Published : 27 Mar 2023
Corresponding Author :

Süleyman Kalaycı: Zonguldak Atatürk State Hospital, Zonguldak, Turkey

[email protected]
Citation : Kalaycı S, Hamamcıoğlu AC, Kalaycı B. The usefulness of arylesterase in predicting contrast-induced nephropathy in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention. J Health Sci Med 2023; 6(2): 244-249.

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