JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

ISSN: Active
eISSN: 2636-8579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
A comparative study of the effects of chronic kidney disease on sonographic arterial stiffness parameters in geriatric and normal population
Abstract
Aims: Due to its growing incidence rate worldwide, chronic kidney disease is a crucial public health problem which is strongly associated with cardiovascular disease. Cardiovascular disease in chronic kidney disease patients is characterized by arteriosclerosis and increased arterial stiffness, and is the leading cause of morbidity and mortality. A correlation was reported between an increased arterial stiffness and cardiovascular disease in high risk groups such as chronic kidney disease or hypertension as well as general undiagnosed population. Our aim was to show the changes in arterial stiffness parameters in patients with chronic kidney disease in the geriatric population. Material and
Methods: 44 chronic kidney disease patients and 44 control group cases of the same age were included in the study. There were 20 female and 24 male cases in each group. Systolic and diastolic diameter were measured for all cases. Intima-media thickness was measured in carotid and femoral arteries. Arterial stiffness parameters were calculated using formulas. Systolic and diastolic arterial blood pressure and body mass index were measured. Their urea and creatinine values were recorded.
Results: There were no differences between two groups in terms of age and sex (p=0.069). Body mass index in the patient group was significantly lower compared to the control group (p=0.025). Systolic arterial blood pressure was higher in the patient group (p<0.001). Arterial stiffness parameters in both arterial systems, particularly in femoral artery, were significantly (p<0.05) worse in the patient group compared to the control group.
Conclusion: Intima-media thickness was measured higher, which overlaps with the existing literature. Femoral parameters were more effective in the prediction of atherosclerosis. Chronic kidney disease affects cardiovascular system negatively, and increases atherosclerosis significantly compared to the normal population.

Keywords : Arterial stiffness, chronic kidney disease, geriatrics, compliance, diastolic wall stress

Download Article


1. Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronickidney disease-a systematic review and meta-analysis. PloS one2016; 11: e0158765..
2. London GM, Safar ME, Pannier B: Aortic aging in ESRD:structural, hemodynamic, and mortality implications. J Am SocNephrol 2016; 27: 1837-46.
3. Mathew RO, Bangalore S, Lavelle MP, et al. Diagnosis andmanagement of atherosclerotic cardiovascular disease in chronickidney disease: a review. Kidney Int 2017; 91: 797-807.
4. Saran R, Li Y, Robinson B, et al. US Renal Data System 2015Annual Data Report: Epidemiology of Kidney Disease in theUnited States. Am J Kidney Dis 2016; 67: Svii S1-305.
5. Ford ML, Tomlinson LA, Chapman TP, Rajkumar C, Holt SG.Aortic stiffness is independently associated with rate of renalfunction decline in chronic kidney disease stages 3 and 4.Hypertension 2010; 55: 1110-5.
6. Taal MW: Arterial stiffness in chronic kidney disease: an update.Current Opinion in Nephrology and Hypertension 2014; 23: 169-73.
7. Baykara M, Demirel A, Yavuzatmaca I, Bilgen M. Response ofarterial stiffness four weeks after terminating short-term aerobicexercise training in a sedentary lifestyle. J Ultrasound Med 2017;36: 353-9.
8. Bansal N: Evolution of cardiovascular disease during thetransition to end-stage renal disease. In: Seminars in Nephrology, Elsevier 2017: 120-31.
9. Dalrymple LS, Katz R, Kestenbaum B, et al. Chronic kidneydisease and the risk of end-stage renal disease versus death. JGeneral Int Med 2011; 26: 379-385.
10. Matsushita K, Van der Velde M, Astor B, et al. Chronic KidneyDisease Prognosis Consortium: Association of estimatedglomerular filtration rate and albuminuria with all-causeand cardiovascular mortality in general population cohorts:a collaborative meta-analysis. Lancet 2010; 375: 2073-81.
11. Tonelli M, Muntner P, Lloyd A, et al. Risk of coronary events inpeople with chronic kidney disease compared with those withdiabetes: a population-level cohort study. Lancet 2012; 380: 807-14.
12. Yerram P, Karuparthi PR, Hesemann L, Horst J, Whaley-ConnellA. Chronic kidney disease and cardiovascular risk. J Am SocHypertens 2007; 1: 178-84.
13. Khamdaeng T, Luo J, Vappou J, Terdtoon P, Konofagou E. Arterialstiffness identification of the human carotid artery using thestress-strain relationship in vivo. Ultrasonics 2012; 52: 402-11.
14. Townsend RR: Arterial stiffness in CKD: a review. Am J KidneyDis 2019; 73: 240-7.
15. Alani H, Tamimi A, Tamimi N. Cardiovascular co-morbidity inchronic kidney disease: Current knowledge and future researchneeds. World J Nephrol 2014; 3: 156-68.
16. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction ofcardiovascular events and all-cause mortality with arterialstiffness: a systematic review and meta-analysis. J Am Coll Cardiol2010; 55: 1318-27.
17. Salvi P, Parati G. Arterial stiffness and renal function&mdash;a complexrelationship. Nat Rev Nephrol 2015; 11: 11-3.
18. Mitchell GF. Arterial stiffness and hypertension. Hypertension2014; 64: 13-8.
19. Vlachopoulos C, Xaplanteris P, Aboyans V, et al. The role ofvascular biomarkers for primary and secondary prevention. Aposition paper from the European Society of Cardiology WorkingGroup on peripheral circulation: Endorsed by the Associationfor Research into Arterial Structure and Physiology (ARTERY)Society. Atherosclerosis 2015; 241: 507-32.
20. Zanoli L, Empana J-P, Perier M-C, et al. Increased carotid stiffnessand remodelling at early stages of chronic kidney disease. JHypertens 2019; 37: 1176-82.
21. Nemcsik J, Kiss I, Tisl&eacute;r A. Arterial stiffness, vascular calcificationand bone metabolism in chronic kidney disease. World J Nephrol2012; 1: 25.
22. McIntyre NJ, Fluck RJ, McIntyre CW, Fakis A, Taal MW.Determinants of arterial stiffness in chronic kidney disease stage3. PLoS One 2013; 8: e55444.
23. Verhave JC, Fesler P, Du Cailar G, Ribstein J, Safar ME, MimranA. Elevated pulse pressure is associated with low renal function inelderly patients with isolated systolic hypertension. Hypertension2005; 45: 586-91.
24. Cesana F, Giannattasio C, Nava S, et al. Impact of blood glucosevariability on carotid artery intima media thickness anddistensibility in type 1 diabetes mellitus. Blood Pressure 2013; 22:355-61.
25. Baykara S, Bozdağ PG, Baykara M, Namlı MN. Evaluation ofarterial stiffness in patients with schizophrenia. J Clin Neurosci2020; 79: 149-53.
26. Sarıca MA, İmam S. Cilostazol decreased carotid arterial stiffnessand increased vertebral arterial flows in patient with peripheralarterial. Ann Vasc Med Res 2016; 3: 1034.
Article available in :
Volume 6, Issue 2, 2023
Page : 294-299
https://doi.org/10.32322/jhsm.1226744
Article Information
Received : 30 Ara 2022
Accepted : 23 Oca 2023
Published : 27 Mar 2023
Corresponding Author :

Kamil Doğan: KSÜ Tıp Fakültesi

[email protected]
Citation : Doğan K, Baykara M, Öztürk C. A comparative study of the effects of chronic kidney disease on sonographic arterial stiffness parameters in geriatric and normal population. J Health Sci Med 2023; 6(2): 294-299.

Read: 170
Cited: 0
Download : 100
_Footer