JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The association between vitamin D level and ICU mortality in COVID-19 patients: a single center survey
Abstract
Aims: Vitamin D, an immune modulator, may contribute COVID-19 infection. This study aims to assess the relationship between vitamin D value and clinical outcomes (need for mechanical ventilation (MV) support and intensive care unit (ICU) mortality) in critically ill patients diagnosed with COVID-19. Material and
Methods: This study included critically ill adult patients diagnosed with COVID-19 infection. Serum vitamin D level was analyzed using liquid chromatography mass spectrometry. Vitamin D concentration was classified as normal (?20 ng/mL) and deficiency (<20 ng/mL). The association between serum vitamin D value and the need for MV treatment and ICU mortality was analyzed by logistic regression model.
Results: Ninety-six critically adult COVID-19 patients with were recruited. The mean age of patients was 68.8±12.6 years. The mean APACHE II score of participants was 14.5±6.7. A total of 69.8% of participants had vitamin D deficiency. Patients with deficiency of vitamin D had significantly higher procalcitonin, BUN and creatinine concentrations than patients with normal vitamin D value (p=0.031, p=0.003, and p=0.001, respectively). Serum vitamin D level was negatively weak correlated with SOFA score (Rho=-0.238, p=0.020), serum creatinine (Rho=-0.299, p=0.003) and troponin levels (Rho=-0.330, p=0.004). Serum vitamin D value was not significantly associated with the need for MV support and ICU mortality (p>0.05).
Conclusion: Approximately 70% of our study sample has below the normal range of serum vitamin D value. Low serum vitamin D concentrations were associated with increased SOFA, creatinine, and troponin concentrations in patients with COVID-19 infection. Vitamin D deficiency was not a predictor of need for MV support and ICU mortality in COVID-19 patients.

Keywords : COVID-19, vitamin D, intensive care unit, mortality

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Article available in :
Volume 6, Issue 2, 2023
Page : 336-341
https://doi.org/10.32322/jhsm.1198621
Article Information
Received : 02 Kas 2022
Accepted : 31 Oca 2023
Published : 27 Mar 2023
Corresponding Author :

Sevda Onuk: Department of Intensive Care, Kayseri City Hospital, University of Health Sciences, Kayseri, Turkey

[email protected]
Citation : Onuk S, Eren E. The association between vitamin D level and ICU mortality in COVID-19 patients: a single center survey. J Health Sci Med 2023; 6(2): 336-341.

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