JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Analysis of perinatal outcomes of pregnancies from consanguineous marriages in a tertiary hospital in Bursa, Turkey
Abstract
Aims: In this article, we aimed to contribute to the outcomes of the consanguineous marriage literature by analyzing fetal results in this population. Material and
Methods: We included 185 patients in this retrospective research. Demographic, clinical, ultrasonographic and delivery data were received from electronic patient records. Also, we recorded the postnatal results, and findings of the infants. By combining all the data, we reported a descriptive analysis of the results of our consanguineous marriage cases with perinatology follow-up.
Results: We had 231 pregnant women in the study, and their mean age was 28.9 years. 117 (50.6%) of the pregnant women had first-degree, and 114 (50.4%) had second-degree consanguineous marriages. Fetal findings were evaluated as usual in 157 (68%) of the pregnant in the ultrasonographic scans performed between prenatal 20-24 weeks of gestation. When we look at the first postnatal examinations of the babies, no abnormal findings were in 134 babies (58.8%). Twenty-two infants (9.6%) were followed up in the neonatal intensive care unit with the diagnosis of transient tachypnea of the newborn, and phototherapy was required in 14 infants (6.1%) due to hyperbilirubinemia. The number of cases requiring surgical intervention after delivery or with significant life-threatening anomalies included 56 findings in 32 infants. There were spina bifida cases in 8 infants and hydrocephalus in 9 infants.
Conclusion: There was an increased level of congenital anomalies associated with consanguineous marriages. Health care centers should educate individuals regarding the negative role of cousin marriages leading to abnormalities in children.

Keywords : Consanguinity, perinatology, congenital abnormalities, down syndrome

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1. Chauhan BG, Yadav D, Jungari S. Association betweenconsanguineous marriage and child nutritional outcomes amongcurrently married women in Pakistan. Clin Epidemiol GlobalHealth 2020; 8: 38-44.
2. Naveed M, Nadeem S, Hassan A, Tanvir I. Association ofconsanguineous marriages with congenital anomalies: Cousinmarriages and birth defects. Pakistan BioMedical J 2019; 2.
3. Abrar S, Safdar W, Hanif M, Shujaat N. Pregnancy outcomes ofconsanguinity among antenatal patients attending combinedmilitary hospital Quetta, Pakistan. J Ayub Medical CollegeAbbottabad 2018; 30: 423-7.
4. Robertson JM, Basany K, Farooq F, et al. Consanguineousmarriage and early pregnancy loss in rural to Peri-Urban India. JObstetr Gynecol India 2022; 72: 314-21.
5. Hamamy H, Antonarakis SE, Cavalli-Sforza LL, et al.Consanguineous marriages, pearls and perils: Genevainternational consanguinity workshop report. Genetics inMedicine 2011; 13: 841-7.
6. Bittles AH, Black ML. The impact of consanguinity on neonataland infant health. Early Human Develop 2010; 86: 737-41.
7. Alharbi KK, Al-Sheikh YA, Alsaadi MM, et al. Screening forobesity in the offspring of first-cousin consanguineous couples:A Phase-I study in Saudi Arabia. Saudi J Biol Sci 2020; 27: 242-6.
8. Anwar S, Taslem Mourosi J, Arafat Y, Hosen MJ. Genetic andreproductive consequences of consanguineous marriage inBangladesh. PloS one 2020; 15: e0241610.
9. Balihallimath RL, Bhusaraddi PS, Shirol VS, Tyagi NK. Percentilesof Pregnancy Outcomes in Consanguineous Marriages. EJMCM2020; 7.
10. Fareed M, Afzal M. Genetics of consanguinity and inbreeding inhealth and disease. Ann Human Biol 2017; 44: 99-107.
11. Brown S. Miscarriage and its associations. In: Seminars inreproductive medicine. © Thieme Medical Publishers; 2008. p.391-400.
12. Maguire A, Tseliou F, O’Reilly D. Consanguineous marriage andthe psychopathology of progeny: a population-wide data linkagestudy. JAMA psychiatry 2018; 75: 438-46.
13. Hamamy H. Consanguineous marriages: preconceptionconsultation in primary health care settings. J CommunityGenetics 2012; 3: 185-92.
14. Bittles AH, Black ML. Consanguinity, human evolution, andcomplex diseases. Proceedings of the National Academy ofSciences 2010; 107: 1779-86.
15. Crowe S, Ridout DA, Knowles R, et al. Death and emergencyreadmission of infants discharged after interventions forcongenital heart disease: a national study of 7643 infants toinform service improvement. J Am Heart Assoc 2016; 5: e003369.
16. Mohammadi MM, Hooman HA, Afrooz GA, Daramadi PS. Therelationship between consanguineous marriage and death in fetusand infants. J Res Med Sci 2012; 17: 448-51.
17. Abbas HA, Yunis K. The effect of consanguinity on neonataloutcomes and health. Human Heredity 2014; 77: 87-92.
18. Yunis K, Mumtaz G, Bitar F, et al. Consanguineous marriage andcongenital heart defects: a case-control study in the neonatalperiod. Am J Med Gen 2006; 140: 1524-30.
19. Hassan AFS, Howsawi BMI, Awwas MY Al, et al. The correlationbetween infants’ congenital heart defects and maternal folic acidsupplementation. Egypt J Hospital Med 2018; 70: 771-6.
20. Mosayebi Z, Movahedian AH. Pattern of congenital malformationsin consanguineous versus nonconsanguineous marriages inKashan, Islamic Republic of Iran. EMHJ-Eastern MediterraneanHealth J 2007; 13: 868-75
21. Tomatır AG, Demirhan H, Sorkun HÇ, Köksal A, Özerdem F,Cilengir N. Major congenital anomalies: a five-year retrospectiveregional study in Turkey. Genetics Moleculer Res 2009; 8: 19-27
Article available in :
Volume 6, Issue 2, 2023
Page : 359-363
https://doi.org/10.32322/jhsm.1233784
Article Information
Received : 13 Oca 2023
Accepted : 06 Şub 2023
Published : 27 Mar 2023
Corresponding Author :

Süleyman Serkan Karaşin: Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey

[email protected]
Citation : Karaşin SS, Güler Kazancı E, Pakay K, et al. Analysis of perinatal outcomes of pregnancies from consanguineous marriages in a tertiary hospital in Bursa, Turkey. J Health Sci Med 2023; 6(2): 359-363.

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