JHSM
Journal of Health Sciences and Medicine

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Original Article
Immature granulocyte and other markers in prediction of mortality in spontaneous intracerebral hemorrhage
Abstract
Aims: This study aims to evaluate immature granulocyte count (IG#) and percentage (IG%) in the prediction of mortality in spontaneous intracerebral hemorrhage (SICH). Material and
Methods: Demographic characteristics and laboratory test results of patients diagnosed with SICH and admitted to the neurology clinic in a tertiary hospital between January 1, 2020, and January 1, 2022, were recorded. One hundred ten patients were included in the study. While 80 of these patients constituted the group that recovered after treatment, 30 of them formed the group that died despite treatment. IG and other laboratory and clinic parameters were statistically compared in both groups.
Results: Of 110 patients, 45 (42.7%) were female, and 65 (57.3%) were male. IG counts were higher in the non-survival group than in the survival group (p=0.001). When the patients were divided according to low IG% (<0.6) and high IG% (>=0.6), 30 patients were in the high IG# group, and 80 patients were in the low IG% group. White blood cell (WBC), neutrophil count (NEUT#), monocyte count (MONO#), IG#, neutrophil-lymphocyte ratio (NLR), and hemorrhage volume (HV) values were statistically significantly higher in the high IG% group than in the low IG% group; Glasgow coma score (GCS) and percentage of lymphocytes (LYMPH%) values were significantly lower too. In addition, the mortality rate in the high IG# group was significantly higher than the mortality rate in the low IG% group (53.23% vs. 17.5%).
Conclusion: IG is a new, easily accessible, inexpensive, and promising marker for predicting in-hospital mortality in patients with SICH.

Keywords : Spontaneous intracerebral hemorrhage, inflammation, immature granulocyte, prognosis, mortality

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1. Broderick JP, Adams Jr HP, Barsan W, et al. Guidelines for themanagement of spontaneous intracerebral hemorrhage: astatement for healthcare professionals from a special writinggroup of the Stroke Council. Am Heart Assoc Stroke 1999; 30:905-15.
2. Tao C, Hu X, Wang J, et al. Admission neutrophil count andneutrophil to lymphocyte ratio predict 90-day outcome inintracerebral hemorrhage. Biomarkers Med 2017; 11: 33-42.
3. &Uuml;nal Y, Barlas AM. Role of increased immature granulocytepercentage in the early prediction of acute necrotizing pancreatitis.Turk J Trauma Emerg Surg 2019; 25: 177-82.
4. Bedel C, Korkut M, Aksoy F, Kuş G. Usefulness of immaturegranulocytes to predict high coronary SYNTAX score in acutecoronary syndrome; a cross-sectional study. Arch Acad EmergMed 2020: 8.
5. Korkut M, Bedel C, Zortuk &Ouml;, Selvi F. Can immature granulocytesindicate mortality in patients with acute ischemic stroke? NeurolAsia 2021; 26: 665-70.
6. Bedel C, Korkut M, Selvi F, Zortuk &Ouml;. The immature granulocytecount is a new predictor of the 30-day mortality in intracerebralhaemorrhage patients: preliminary study. Indian J Neurosurg2021; 10: 114-20.
7. Korkut M, Bedel C, Sivil R, et al. Usefulness of immaturegranulocytes as a prognostic factor in st-elevation myocardialınfarction. Brazilian J Cardiovasc Surg 2022; 37: 6.
8. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio predicts the outcome of acute intracerebralhemorrhage. Stroke 2016; 47: 1654-7.
9. Al-Mufti F, Amuluru K, Damodara N, et al. Admission neutrophil-lymphocyte ratio predicts delayed cerebral ischemia followinganeurysmal subarachnoid hemorrhage. J NeurointerventionalSurg 2019; 11: 1135-40.
10. Walsh KB, Sekar P, Langefeld CD, et al. Monocyte count and 30-day case fatality in intracerebral hemorrhage. Stroke 2015; 46:2302-4.
11. Zhang W, Shen Y. Platelet-to-lymphocyte ratio as a new predictiveindex of neurological outcomes in patients with acute intracranialhemorrhage: a retrospective study. Medical Science Monitor: IntMed J Experiment Clin Res 2018; 24: 4413.
12. Bhatia R, Singh H, Singh S, et al. A prospective study of in-hospitalmortality and discharge outcome in spontaneous intracerebralhemorrhage. Neurol India 2013; 61: 244.
13. Iso H, Jacobs Jr DR, Wentworth D, et al. Serum cholesterol levelsand six-year mortality from stroke in 350,977 men screened forthe multiple risk factor intervention trial. New Engl J Med 1989;320: 904-10.
14. Takahashi O, Cook EF, Nakamura T, et al. Risk stratification forin-hospital mortality in spontaneous intracerebral haemorrhage:a Classification and Regression Tree analysis. J Assoc Physicians2006; 99: 743-50.
15. Hwang BY, Bruce SS, Appelboom G, et al. Evaluation ofintraventricular hemorrhage assessment methods for predictingoutcome following intracerebral hemorrhage. J Neurosurg 2012;116: 185-92.
16. Godoy DA, Pinero G, Di Napoli M. Predicting mortality inspontaneous intracerebral hemorrhage: can modification tooriginal score improve the prediction? Stroke 2006; 37: 1038-44.
17. Lima LR, Cunha GS, Nogueira KS, Comar SR. Automatedimmature granulocyte count in patients of the intensive care unitwith suspected infection. J Brasileiro de Patologia e MedicinaLaboratorial 2019; 55: 267-80.
18. &Uuml;nal Y. A new and early marker in the diagnosis of acutecomplicated appendicitis: immature granulocytes. Ulus TravmaAcil Cerrahi Derg 2018; 24: 434-9.
19. Daix T, Gu&eacute;rin E, Tavernier E, et al. Immature granulocytes: arisk factor of infection after cardiac surgery. Cytometry Part B:Clinical Cytometry 2018; 94: 887-94.
20. Karakulak S, Narcı H, Ayrık C, Erdoğan S, &Uuml;&ccedil;bilek, E. Theprognostic value of immature granulocyte in patients with acutepancreatitis. Am J Emerg Med 2021; 44: 203-7.
21. Monteiro J&uacute;nior JGDM, de Oliveira Cipriano Torres D.Hematological parameters as prognostic biomarkers in patientswith cardiovascular diseases. Curr Cardiol Rev 2019; 15: 274-82.
Article available in :
Volume 6, Issue 2, 2023
Page : 368-373
https://doi.org/10.32322/jhsm.1225428
Article Information
Received : 27 Ara 2022
Accepted : 08 Şub 2023
Published : 27 Mar 2023
Corresponding Author :

İdris Kocatürk: Department of Neurology, Faculty of Medicine, Kastamonu University, Kastamonu, Turkiye

[email protected]
Citation : Kocatürk İ, Gülten S. Immature granulocyte and other markers in prediction of mortality in spontaneous intracerebral hemorrhage. J Health Sci Med 2023; 6(2): 368-373.

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