JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

ISSN: Active
eISSN: 2636-8579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
Predictive value of inflammatory markers in gastric cancer
Abstract
Aims: Many recent studies are increasingly shedding light on the nature of the relationship between cancer and inflammation. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) platelet/neutrophil ratio (PNR), and Mean Platelet Volume (MPV) are proinflammatory markers, and their prognostic importance has been investigated in many solid cancers. In this study, we discussed the association of these derivative inflammatory markers, obtained from a cheap and simple peripheral blood test, with clinicopathologic variables in patients undergoing gastrectomy for gastric cancer. Material and
Methods: The retrospective database of a total of 148 patients who were operated for gastric cancer in the Diyarbakır Gazi Yaşargil Training and Research Hospital Department of Surgery was analyzed. All blood results and pathology reports of the patients were reviewed retrospectively. Demographic characteristics of the patients and pathological features of the tumor were extracted from the database. NLR, PLR, PNR and MPV values were calculated from peripheral blood cell counts. Data were analyzed using SPSS version 24.0.
Results: PNR and MPV values were statistically significant according to N and T stage of the tumor, respectively (p=0.035, p=0.011). In MPV, this difference was statistically observed between T1 and T2 tumors (p=0.029). PLR and NLR values did not show a significant difference according to the size of the tumor (p>.05).
Conclusion: MPV values are significantly associated with tumor T stage. PNR values are significantly associated with tumor N stage. However, the clinical implications and the added value to clinical practice require further research.

Keywords : Inflammatory marker, gastric cancer, NLR, PLR, T stage

Download Article


1. Ludwig JA, Weinstein JN. Biomarkers in cancer staging, prognosisand treatment selection. Nat Rev Cancer 2005; 5: 845-56.
2. Çaparlar MA, Uçar Y, Dokcu Ş, Hasırcı İ, Ulutaş ME, Erşen O.Procalcitonin: the ideal predictor of anastomotic leakage. But,when? Int Surg J 2021; 8: 1418.
3. Çaparlar MA, Uçar Y, Dokcu Ş, Hasirci I, Ulutaş ME, Erşen O. Therelationship between procalcitonin with morbidity, mortality andsurvival in gastric cancer. J Adv Med Med Res 2021; 33: 80-91.
4. Dokcu S, Caparlar M. C-Reactive protein to albumin ratio topredict postoperative complications after gastrectomy for gastriccancer. Med Sci | Int Med J 2021; 10: 1087.
5. Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: Links togenetic instability. Carcinogenesis 2009; 30: 1073-81.
6. Kuniyoshi RK, de Sousa Gehrke F, Alves BCA, et al. Gene profilingand circulating tumor cells as biomarker to prognostic of patientswith locoregional breast cancer. Tumor Biol 2015; 36: 8075-83.
7. Powell AGMT, Parkinson D, Patel N, Chan D, Christian A, LewisWG. Prognostic significance of serum inflammatory markers ingastric cancer. J Gastrointest Surg 2018; 22: 595-605.
8. Proctor MJ, McMillan DC, Morrison DS, Fletcher CD, HorganPG, Clarke SJ. A derived neutrophil to lymphocyte ratio predictssurvival in patients with cancer. Br J Cancer 2012; 107: 695-9.
9. Yodying H, Matsuda A, Miyashita M, et al. Prognostic significanceof neutrophil-to-lymphocyte ratio and platelet-to-lymphocyteratio in oncologic outcomes of esophageal cancer: a systematicreview and meta-analysis. Ann Surg Oncol 2016; 23: 646-54.
10. Zhu Y, Sun Q, Qin B, Zhao W, Yang J, Si W. Platelet-lymphocyteratio acts as an indicator of poor prognosis in patients with breastcancer. Oncotarget 2017; 8: 1.
11. Stotz M, Gerger A, Eisner F, et al. Increased neutrophil-lymphocyteratio is a poor prognostic factor in patients with primary operableand inoperable pancreatic cancer. Br J Cancer 2013; 109: 416-21.
12. Dokcu Ş, Çaparlar MA, Eroğlu A. The relationship between theneutrophil-lymphocyte ratio and platelet- lymphocyte ratio andtumor characteristics in patients with breast cancer. Ann ClinAnal Med 2021; 12: 274-7.
13. Koh CH, Bhoo-Pathy N, Ng KL, et al. Utility of pre-treatmentneutrophil-lymphocyte ratio and platelet-lymphocyte ratio asprognostic factors in breast cancer. Br J Cancer 2015; 113: 150-8.
14. Wariss BR, de Souza Abrahão K, de Aguiar SS, Bergmann A,Thuler LCS. Effectiveness of four inflammatory markers inpredicting prognosis in 2374 women with breast cancer. Maturitas2017; 101: 51-6.
15. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209-49.
16. Balkwill FR, Mantovani A. Cancer-related inflammation:common themes and therapeutic opportunities. Semin CancerBiol 2012; 22: 33-40.
17. Jonathan Cools-Lartigue JS at all. Neutrophil extracellular trapssequester circulating tumor cells and promote metastasis. J ClinInvest 2013; 123: 34-46.
18. McMillan DC. Systemic inflammation, nutritional status andsurvival in patients with cancer. Curr Opin Clin Nutr Metab Care2009; 12: 223-6.
19. Templeton AJ, Ace O, McNamara MG, et al. Prognostic role ofplatelet to lymphocyte ratio in solid tumors: A systematic reviewand meta-analysis. Cancer Epidemiol Biomarkers Prev 2014; 23:1204-12.
20. Denkert C, Loibl S, Noske A, et al. Tumor-associated lymphocytesas an independent predictor of response to neoadjuvantchemotherapy in breast cancer. J Clin Oncol 2010; 28: 105-13.
21. Azab B, Shah N, Radbel J, et al. Pretreatment neutrophil/lymphocyte ratio is superior to platelet/lymphocyte ratio as apredictor of long-term mortality in breast cancer patients. MedOncol 2013; 30: 1.
22. Ikeda M, Furukawa H, Imamura H. Poor prognosis associatedwith thrombocytosis in patients. Annals Surg Oncol 2002; 9:287-91.
23. Bambace NM, Holmes CE. The platelet contribution to cancerprogression. J Thromb Haemost 2011; 9: 237-49.
24. Ying HQ, Deng QW, He BS, et al. The prognostic value ofpreoperative NLR, d-NLR, PLR and LMR for predicting clinicaloutcome in surgical colorectal cancer patients. Med Oncol 2014;31: 1-8.
25. Jung MR, Park YK, Jeong O, et al. Elevated preoperative neutrophilto lymphocyte ratio predicts poor survival following resection inlate stage gastric cancer. J Surg Oncol 2011; 104: 504-10.
26. Lee S, Oh SY, Kim SHet al. Prognostic significance of neutrophillymphocyte ratio and platelet lymphocyte ratio in advancedgastric cancer patients treated with FOLFOX chemotherapy. BMCCancer 2013; 13: 1-11.
27. Koh CH, Bhoo-Pathy N, Ng KL, et al. Utility of pre-treatmentneutrophil-lymphocyte ratio and platelet-lymphocyte ratio asprognostic factors in breast cancer. Br J Cancer 2015; 113: 150-8.
28. Liu C, Huang Z, Wang QS, et al. Usefulness of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in hormone-receptor-negative breast cancer. Onco Targets Ther 2016; 9: 4653-60. </ol> </div> <p>
Article available in :
Volume 6, Issue 2, 2023
Page : 552-556
https://doi.org/10.32322/jhsm.1230078
Article Information
Received : 05 Oca 2023
Accepted : 24 Mar 2023
Published : 27 Mar 2023
Corresponding Author :

Salim İlksen Başçeken: Department of Surgical Oncology, Gazi Yaşargil Training and Research Hospital, Health Sciences University, Diyarbakır, Turkey

[email protected]
Citation : Başçeken Sİ, Tikici D. Predictive value of inflammatory markers in gastric cancer. J Health Sci Med 2023; 6(2): 552-556.

Read: 134
Cited: 0
Download : 89
_Footer