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Journal of Health Sciences and Medicine

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Original Article
Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study
Abstract
Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 (B12), vitamin D (Vit-D), folic acid, and iron deficiency, on Hashimoto's thyroiditis (HT) disease. This differs from existing literature that has examined these parameters individually.
Methods: The study evaluated age, gender, thyroid stimulating hormone (TSH), free-T4 (FT4), free-T3 (FT3), Vit-D levels, as well as autoantibodies against thyroid peroxidase (anti-TPO) and anti-tyroglobulin iron (anti-TG) levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients' routine blood test results using automated analysis methods.
Results: A negative correlation was found between the blood, Vit-D level and anti-TG (as the vit-D value increases, the anti-TG decreases) (r=-0.417; p=0.001; p<0.01). There was a statistically significant and weak correlation between blood Vit-D measurements and anti-TPO measurements (r=-0.341; p=0.005; p<0.01).
Conclusion: The study findings demonstrated that there was no statistically significant difference in the measurements and correlation between hemoglobin, FT3, FT4, TSH, ferritin, vitamin B12, and folic acid levels in patients with and without a diagnosis of HT (p>0.05). However, the study emphasized the critical role of vitamin D in the pathophysiology and treatment. of HT. Furthermore, molecular docking simulations indicated that folic acid could potentially act as a potent inhibitor of human extracellular signal-regulated kinase (ERK2), which has been reported to play a key role in HT.

Keywords : Hashimoto's thyroiditis, otoimmun disease, vitamin D, anti-TPO, ferritin, vitamin B12

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Article available in :
Volume 6, Issue 4, 2023
Page : 705-712
https://doi.org/10.32322/jhsm.1243597
Article Information
Received : 28 Oca 2023
Accepted : 28 May 2023
Published : 30 Tem 2023
Corresponding Author :

Elif Sibel Aslan: Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, İstanbul, Turkey

[email protected]
Citation : Aslan ES, Gür S. Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study. J Health Sci Med. 2023;6(4):705-712

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