JHSM
Journal of Health Sciences and Medicine

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Original Article
The relationship between osteoporosis and non-dipper hypertension in postmenopausal women
Abstract
Aims: Previous studies have shown association between hypertension and osteoporosis, however has not been evaluated alterations of circadian blood pressure patterns. The present study investigated the effects of osteoporosison the circadian blood pressure assessed by ambulatory blood pressure monitoring.
Methods: 68 patients (mean age: 61.3±8.7 years, 34 dipper and 34 non-dipper patients) with postmenopausal hypertension (HT) were prospectively enrolled in this study. Ambulatory blood pressure monitoring was performed on all patients. We measured bone mineral density (BMD) and T-score by dual X- ray absorptiometry at the lumbar spine. The receiver operating characteristics (ROC) curve was used to demonstrate the sensitivity and specificity of lumbar spine BMD, optimal cut - off value for predicting non-dipper hypertension (NDHT).
Results: T-score and BMD in non-dipper patients were lower than the dipper patients. There was a significant correlation between the rate of fall in night of mean blood pressure and both lumbar spine T-score and lumbar spine BMD (r= 0.330 and P =0.006 vs r=0.322 and P =0.007, respectively). A lumbar spine BMD <0.944 g/cm2 measured by DXA had a 64.7% sensitivity and 64.7% specificity in predicting non-dipper hypertension at ROC curve analysis.
Conclusion: Low lumbar spine BMD is an independent and strong predictor of non-dipper hypertension. Osteoporosis may be an indicator of cardiovascular risk. Therefore, osteoporotic patients should be treated more aggressively.

Keywords : Menopause, non-dipper hypertension, osteoporosis

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Article available in :
Volume 6, Issue 5, 2023
Page : 898-904
https://doi.org/10.32322/jhsm.1302874
Article Information
Received : 26 May 2023
Accepted : 11 Ağu 2023
Published : 28 Eyl 2023
Corresponding Author :

Tolga Çakmak: Departman of Cardiology, Balıkesir Atatürk City Hospital, University of Health Sciences, Balıkesir, Turkey

[email protected]
Citation : Çakmak T, Kadife İ, Ayhan E, Işık T. The relationship between osteoporosis and non-dipper hypertension in postmenopausal women. J Health Sci Med. 2023;6(5):898-904.

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