JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

ISSN: Active
eISSN: 2636-8579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
Characteristics and effects of headaches on quality of life in individuals with epilepsy in Çorum province of Turkey
Abstract
Aims: Varying headache prevalence rates have been reported in individuals with epilepsy in the literature. This study was investigate the frequency and types of headaches in individuals with epilepsy, and the impact of headaches on the clinical features and quality of life in this patient group.
Methods: 150 individuals with epilepsy, 83 female and 67 male, were included in the study sample by random sampling method. Headaches were primarily defined as pre-ictal, ictal, and post-ictal headaches according to the temporal relationship with seizures. Headaches that were not temporally related to seizures were defined as inter-ictal headaches. Types and features of participants’ headaches were evaluated using the headache questionnaire consisting of 35 questions. Individuals’ quality of life was evaluated using the Quality of Life in Epilepsy Inventory (QOLIE-10).
Results: Of the 150 participants included in the study, 73.33% had generalized, 20% focal, and 6.66% combined generalized focal epilepsy, and 41.33% had accompanying headache complaints. Of the participants with headaches, 35.48% were male and 64.51% were female. Inter-ictal headache, which was detected in 72.58% participants, was the most common type of headache. Tension and migrainous type headaches were more common among participants with inter-ictal headache, whereas migrainous type headaches were more common among participants with pre- and post-ictal headaches. There were statistically significant differences in the scores obtained from all three subscales of QOLIE-10 inventory between the participants with and without headache. Accordingly, quality of life was worse in the headache group than in the headache-free group (p<0.05).
Conclusion: Although clinicians focus more on diagnosis and treatment in the context of epilepsy, the treatment of comorbidities is also important. In this context, it is likely that accurate diagnosis of headaches in individuals with epilepsy and treating headaches along with epilepsy will significantly reduce the burden of disease in this patient group.

Keywords : Headache, migraine, tension headache, epilepsy, quality of life

Download Article


1. Olesen J, Gobel H. Headache classification committeeof the international headache society (IHS). Theinternational classification of headache disorders, 3rdedition (beta version). Cephalalgia. 2013;33(9):629-808.doi:10.1177/0333102413485658
2. Cianchetti C, Pruna D, Ledda M. Epileptic seizures and headache/migraine: A review of types of association and terminology.Seizure. 2013;22:679-685. doi:10.1016/j.seizure.2013.05.017
3. Tsiropoulos I, Sidaros AS. New classification of epileptic seizuresand the epilepsies. Ugeskr Laeger. 2022;184(26):V03220159
4. Bauer PR, Tolner EA, Keezer MR, Ferrari MD, Sande JW. Headachein people with epilepsy. Nat Revi Neurol. 2021;17(9):529-544. doi:10.1038/s41582-021-00516-6
5. Atalar A&Ccedil;, T&uuml;rk BG, Ekizoglu E, et al. Headache in idiopathic/genetic epilepsy: cluster analysis in a large cohort. Epilepsia. 2022;63:1516-1529. doi:10.1111/epi.17205
6. Bensken WP, Fernandez-Baca Vaca G, Jobst BC, et al. Burdenof chronic and acute conditions and symptoms in people withepilepsy. Neurology. 2021;97(24):2368-2380. doi:10.1212/WNL.0000000000012975
7. &Ouml;zer G, &Uuml;nal Y, Kutlu G, G&ouml;mceli Y, İnan L. Prevalence of interictalheadache in patients with epilepsy. Epilepsi. 2018;24(2):51-54.doi:10.14744/epilepsi.2018.26928
8. Kim DW, Lee SK. Headache and epilepsy. J Epilepsy Res.2017;7(1):7-15. doi:10.14581/jer.17002
9. Sutherland HG, Albury CL, Griffiths LR. Advances in genetics ofmigraine. J Headache Pain. 2019;20(1):72. doi:10.1186/s10194-019-1017-9
10. Dedei Daryan M, Guveli BT. Prevalence and clinical characteristicsof headache in juvenile myoclonic epilepsy:experience froma tertiary epilepsy center. Neurol Sci. 2018;39(3):519-525.doi:10.1007/s10072-017-3232-y
11. Kingston WS, Schwedt TJ. The relationship between headacheswith epileptic and non-epileptic seizures: a narrative review. CurrPain Headache Rep. 2017;21(3):17. doi:10.1007/s11916-017-0617-9
12. Nesterovsky YE, Zavadenko NN. Comorbidity of migraine andepilepsy in childhood. Zh Nevrol Psikhiatr Im S S Korsakova.2018;118(4):100-106. doi:10.17116/jnevro201811841100-106
13. Nuottamo ME, H&auml;pp&ouml;l&auml; P, Artto V, et al. NCOR2 is a novelcandidate gene for migraine-epilepsy phenotype. Cephalalgia.2022;42:631-644. doi:10.1177/03331024211068065
14. Y Lin, M Ding, Q Gong, Z Xiao. Downregulation of GABAAR&alpha;1aggravates comorbidity of epilepsy and migraine via the TLR4signaling pathway. Brain Sci. 2022;12(11):1436. doi:10.3390/brainsci12111436
15. F&ouml;rderreuther S, M&uuml;ller A, Straube A. Haufigkeit und klassifikationpostiktaler kopfschmerzen: eine epidemiologische untersuchung.Akt Neurol. 1998;25:159
16. Ito M, Adachi N, Nakamura F, et al. Characteristics of post-ictal headache in patients with partial epilepsy. Cephalalgia.2004;24(1):23-28. doi:10.1111/j.1468-2982.2004.00628.x
17. HELP (Headache in Epileptic Patients) Study Group. Multi-centerstudy on migraine and seizure-related headache in patients withepilepsy. Yonsei Med J. 2010;51(2):219-224. doi:10.3349/ymj.2010.51.2.219
18. Honari B, Homam SM, Nabipour M, Mostafavian Z, Farajpour A,Sahbaie N. Epilepsy and quality of life in iranian epileptic patients.J Patient Rep Outcomes. 2021;5(1):1-7. doi:10.1186/s41687-021-00292-3
19. Alanis-Guevara I, Pe&ntilde;a E, Corona T, L&oacute;pez -Ayala T, L&oacute;pez-Meza E, L&oacute;pez-G&oacute;mez M. Sleep disturbances, socioeconomicstatus, and seizure control as main predictors of quality of lifein epilepsy. Epilepsy Behav. 2005;7(3):481-485. doi:10.1016/j.yebeh.2005.06.010
20. Edefonti V, Bravi F, Turner K, et al. Health-related quality oflife in adults with epilepsy: the efect of age, age at onset andduration of epilepsy in a multicentre italian study. BMC Neurol.2011;2011;11(33):1-13. doi:10.1186/1471-2377-11-33
21. Malik NI, Fatima R, Ullah I, et al. Perceived stigma, discriminationand psychological problems among patients with epilepsy. FrontPsychiatry. 2022;13:1000870. doi:10.3389/fpsyt.2022.1000870
22. Sakurai H, Kanemoto K. Quality of life for patients with psychogenicnonepilepsy seizures in comparison with age- and gender-matchedpatients with epilepsy-cross-sectional study. Epilepsy Behav.2022;128:108539. doi:10.1016/j.yebeh.2021.108539
23. Henning O, Buer C, Nakken KO, Lossius MI. People with epilepsystill feel stigmatized. Acta Neurologica Scand. 2021;144(3):312-316. doi:10.1111/ane.13449.
Article available in :
Volume 6, Issue 5, 2023
Page : 943-947
https://doi.org/10.32322/jhsm.1307268
Article Information
Received : 31 May 2023
Accepted : 19 Ağu 2023
Published : 28 Eyl 2023
Corresponding Author :

Sinan Eliaçık: Department of Neurology, Faculty of Medicine, Hitit University, Çorum, Turkey

[email protected]
Citation : Eliaçık S, Aykaç S. Characteristics and effects of headaches on quality of life in individuals with epilepsy in Çorum province of Turkey. J Health Sci Med. 2023;6(5):943-947.

Read: 247
Cited: 0
Download : 176
_Footer