JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The effect of COVID-19 vaccines on thyroid function and thyroid autoimmunity
Abstract
Aims: There have been reports about various thyroid autoimmune events after SARS-CoV-2 vaccinations. There is limited data on the extent to which vaccines for COVID-19 are effective on thyroid autoimmunity. This study investigates how COVID-19 vaccination affects thyroid antibodies and functions in individuals without any thyroid disease history.
Methods: The study evaluated individuals aged 18-65 with no previous COVID-19 history or thyroid disease who had at least two COVID-19 vaccine doses (CoronaVac + Pfizer-BioNTech or Pfizer-BioNTech alone) between October 2021 and October 2022. All participants' thyroid hormone (free triiodothyronine, thyroid-stimulating hormone, and free thyroxine) and thyroid autoantibody (anti-thyroglobulin, antithyroid peroxidase, and TSH receptor antibody) levels were measured.
Results: The study included 92 individuals in total. Thyroid functions and antithyroid antibody levels were found to be in the normal range before the implementation of the SARS-CoV-2 vaccine. Of the study participants, 42 received the Sinovac + BioNTech vaccine, and 50 received the BioNTech vaccine alone. While a decrease in st4 value was observed only in the BioNTech group after vaccination (p=0.007), thyroid dysfunction was not observed in any participant. After vaccination, TRAB positivity was observed in one participant, ANTI-TPO positivity in six participants, and ANTI-TG positivity in eight participants. No statistically significant antibody positivity was detected. No participants with antibody positivity displayed thyroid dysfunction.
Conclusion: Although some positivity in terms of antithyroid antibodies was observed after COVID-19 vaccination, this antibody positivity did not have a statistically significant level, and thyroid dysfunction was not detected in any participant. The COVID-19 vaccine is safe for thyroid function and autoimmunity.

Keywords : COVID-19, Sinovac, BioNTech, anti-thyroid peroxidase, anti-thyroglobulin, TSH receptor antibody

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Article available in :
Volume 6, Issue 5, 2023
Page : 948-953
https://doi.org/10.32322/jhsm.1326088
Article Information
Received : 13 Tem 2023
Accepted : 21 Ağu 2023
Published : 28 Eyl 2023
Corresponding Author :

Işılay Taşkaldıran: Department of Endocrinology and Metabolism, Faculty of Medicine, Başkent University, Ankara, Turkey

[email protected]
Citation : Taşkaldıran I, Altay FP, Bozkuş Y, et al. The effect of COVID-19 vaccines on thyroid function and thyroid autoimmunity. J Health Sci Med. 2023;6(5):948-953.

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