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Journal of Health Sciences and Medicine

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Original Article
Assessment of vitamin D deficiency and hyperparathyroidism in metabolically healthy and unhealthy obese patients
Abstract
Aims: This study aimed to compare the levels of vitamin D in metabolically healthy (MHO) and metabolically unhealthy obese (MUO) individuals and determine if there are differences between these two groups concerning vitamin D deficiency and hyperparathyroidism.
Methods: A total of 263 obese female patients were included in the study and divided into two groups based on metabolic syndrome diagnostic criteria. Biochemical and anthropometric data obtained after a 12-hour fasting period were analyzed.
Results: Among the patients, the average 25-OH vitamin D level was 10.9±6.5 ng/ml. A total of 242 patients (92%) had vitamin D deficiency, and 132 patients (50.2%) were diagnosed with hyperparathyroidism. Significant differences were found in vitamin D (p=0.003) and uric acid (p<0.001) levels between the MHO and MUO groups. Additionally, the groups with vitamin D deficiency showed significantly different glucose (p=0.026) and homeostatic model assessment for insulin resistance (p=0.042) values. Patients with hyperparathyroidism had higher waist circumference (p<0.001), waist-to-hip ratio (p=0.018), BMI (p=0.006), and systolic (p=0.001) and diastolic (p<0.001) blood pressure values compared to those with normal parathyroid hormone levels.
Conclusion: The study emphasizes the importance of monitoring vitamin D deficiency and hyperparathyroidism in obese patients, as these conditions are more prevalent in this population and might be associated with metabolic syndrome parameters, increasing cardiometabolic risk.

Keywords : Vitamin D deficiency, obesity, hyperparathyroidism, metabolic syndrome, cardiovascular disease

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1. The GBD 2015 Obesity Collaborators. Health effects ofoverweight and obesity in 195 countries over 25 years. N Engl JMed . 2017;377(1):13-27.
2. Stival C, Lugo A, Odone A, et al. Prevalence and correlates ofoverweight and obesity in 12 European Countries in 2017-2018.Obes Facts. 2022;15(5):655-665.
3. Magkos F. Metabolically healthy obesity: what-s in a name? Am JClin Nutr. 2019;110(3):533-539. doi:https://doi.org/10.1093/ajcn/nqz133
4. Smith GI, Mittendorfer B, Klein S. Metabolically healthy obesity:facts and fantasies. J Clin Invest. 2019;129(10):3978-3989.
5. Szymczak-Pajor I, Sliwinska A. Analysis of associationbetween vitamin D deficiency and insulin resistance. Nutrients.2019;11(4):794.
6. Doğan M, Doğan AG, Hastanesi A, et al. Vitamin D yetersizliğive eksikliğine g&uuml;ncel yaklaşım. J Health Sci Med. 2019;2(2):58-61.doi:10.32322/JHSM.496326
7. Vranic L, Mikola&scaron;evic I, Milic S. Vitamin D deficiency: consequenceor cause of obesity? Medicina (B Aires). 2019;55(9):541.
8. Karampela I, Sakelliou A, Vallianou N, Christodoulatos GS,Magkos F, Dalamaga M. Vitamin D and obesity: currentevidence and controversies. Curr Obes Rep. 2021;10(2):162-180.doi:10.1007/S13679-021-00433-1/FIGURES/1
9. Trimarco V, Manzi MV, Mancusi C, et al. Insulin resistanceand vitamin D deficiency: a link beyond the appearances. FrontCardiovasc Med. 2022;9:859793.
10. Şabanoğlu C, İnan&ccedil; İH. The relationship between vitamin Ddeficiency and hypertensive organ damage. J Health Sci Med.2022;5(6):1704-1712. doi:10.32322/jhsm.1173794
11. Ford ES, Zhao G, Li C, Pearson WS. Serum concentrations ofvitamin D and parathyroid hormone and prevalent metabolicsyndrome among adults in the United States. J Diabetes.2009;1(4):296-303. doi:10.1111/J.1753-0407.2009.00046.X
12. Grethen E, McClintock R, Gupta CE, et al. Vitamin D andhyperparathyroidism in obesity. J Clin Endocrinol Metab. 2011;96(5):1320-1326.
13. Andersen T, McNair P, Hyldstrup L, et al. Secondaryhyperparathyroidism of morbid obesity regresses during weightreduction. Metabolism. 1988;37(5):425-428.
14. Grundy SM, Cleeman JI, Merz CNB, et al. Implications of recentclinical trials for the national cholesterol education program adulttreatment panel III guidelines. Circulation. 2004;110(2):227-239.
15. T&uuml;rkiye Endokrinoloji ve Metabolizma Derneği Obezite LipidMetabolizmasi Hipertansiyon &Ccedil;alişma Grubu. TEMD ObeziteTanı ve Tedavi Kılavuzu 2019. TEMD; 2019.
16. Cigerli O, Parildar H, Unal AD, Tarcin O, Erdal R, Guvener DemiragN. Vitamin D deficiency is a problem for adult out-patients? Auniversity hospital sample in İstanbul, Turkey. Public Health Nutr.2013;16(7):1306-1313. doi:10.1017/S1368980012003588
17. Cinar N, Harmanci A, Yildiz BO, Bayraktar M. Vitamin Dstatus and seasonal changes in plasma concentrations of25-hydroxyvitamin D in office workers in Ankara, Turkey. Eur JIntern Med. 2014;25(2):197-201. doi:10.1016/J.EJIM.2013.11.004
18. G&ouml;ktaş O, Ersoy C, Ercan I, Can FE. Vitamin D status in the adultpopulation of Bursa-Turkey. Eur J Gen Pract. 2020;26(1):156-162.doi:10.1080/13814788.2020.1846712
19. Walsh JS, Bowles S, Evans AL. Vitamin D in obesity. Curr OpinEndocrinol Diabetes Obes. 2017;24(6):389-394. doi:10.1097/MED.0000000000000371
20. Pourshahidi LK. Vitamin D and obesity: current perspectives andfuture directions. Proc Nutr Soc. 2015;74(2):115-124. doi:10.1017/S0029665114001578
21. Osmancevic A, Gillstedt M, Landin-Wilhelmsen K, et al. Sizeof the exposed body surface area, skin erythema and body massindex predict skin production of vitamin D. J Photochem PhotobiolB . 2015;149:224-229.
22. Bell N, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.Evidence for alteration of the vitamin D-endocrine system inobese subjects. Am Soc Clin Investig. 1985:370-373.
23. Schmitt EB, Nahas-Neto J, Bueloni-Dias F, Poloni PF, Orsatti CL,Petri Nahas EA. Vitamin D deficiency is associated with metabolicsyndrome in postmenopausal women. Maturitas. 2018;107:97-102. doi:10.1016/j.maturitas.2017.10.011
24. Botella-Carretero JI, Alvarez-Blasco F, Villafruela JJ, Balsa JA,V&aacute;zquez C, Escobar-Morreale HF. Vitamin D deficiency isassociated with the metabolic syndrome in morbid obesity. ClinNutr. 2007;26(5):573-580. doi:10.1016/J.CLNU.2007.05.009
25. Lee SJ, Lee EY, Lee JH, et al. Associations of serum25-hydroxyvitamin D with metabolic syndrome and itscomponents in elderly men and women: The Korean Urban RuralElderly cohort study. BMC Geriatr. 2019;19(1):1-8. doi:10.1186/S12877-019-1118-Y/TABLES/5
26. Zhu W, Heil DP. Associations of vitamin D status with markersof metabolic health: a community-based study in Shanghai,China. Diabetes Metab Syndr. 2018;12(5):727-732. doi:10.1016/J.DSX.2018.04.010
27. Kamycheva E, Sundsfjord J, Jorde R. Serum parathyroid hormonelevel is associated with body mass index. The 5th Tromso study.Eur J Endocrinol. 2004;151(2):167-172. doi:10.1530/eje.0.1510167
28. Bolland MJ, Grey AB, Ames RW, Horne AM, Gamble GD, ReidIR. Fat mass is an important predictor of parathyroid hormonelevels in postmenopausal women. Bone. 2006;38(3):317-321.doi:10.1016/j.bone.2005.08.018
29. Pitroda AP, Harris SS, Dawson-Hughes B. The association ofadiposity with parathyroid hormone in healthy older adults.Endocrine. 2009;36(2):218-223. doi:10.1007/S12020-009-9231-X/TABLES/4
30. Stein EM, Strain G, Sinha N, et al. Vitamin D insufficiency priorto bariatric surgery: risk factors and a pilot treatment study.Clin Endocrinol (Oxf). 2009;71(2):176-183. doi:10.1111/J.1365-2265.2008.03470.X
31. Fish E, Beverstein G, Olson D, Reinhardt S, Garren M, Gould J.Vitamin D status of morbidly obese bariatric surgery patients. JSurg Res. 2010;164(2):198-202. doi:10.1016/J.JSS.2010.06.029
32. Salazar DA, Ferreira MJS, Neves JS, et al. Variable Thresholdsof Vitamin D Plasma Levels to Suppress PTH: the Effect ofWeight and Bariatric Surgery. Obes Surg. 2020;30(4):1551-1559.doi:10.1007/S11695-019-04351-Z/TABLES/7
Article available in :
Volume 6, Issue 5, 2023
Page : 968-973
https://doi.org/10.32322/jhsm.1331970
Article Information
Received : 24 Tem 2023
Accepted : 24 Ağu 2023
Published : 28 Eyl 2023
Corresponding Author :

Nergis Akbaş: Department of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkey

[email protected]
Citation : Akbaş N, Akbaş EM. Assessment of vitamin D deficiency and hyperparathyroidism in metabolically healthy and unhealthy obese patients. J Health Sci Med. 2023;6(5):968-973.

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