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Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Impact of Ramadan fasting on eGFR in patients with late stage chronic kidney disease
Abstract
Aims: Ramadan fasting is a significant religious practice observed annually by approximately 1.9 billion adult Muslims worldwide. However, its potential impact on kidney health in individuals with chronic kidney disease (CKD) remains a subject of concern. This study aimed to investigate the effects of Ramadan fasting on renal function in patients with stage 3-5 CKD and to identify any associated risk factors.
Methods: A single-center, self-controlled longitudinal observational study was conducted on 192 stable patients with stage 3-5 CKD who observed Ramadan fasting. The fasting period was about 14-15 hours per day for one month Various clinical parameters, including eGFR, blood urea nitrogen (BUN), sodium (Na+), potassium (K+), calcium (Ca++), phosphorus, parathyroid hormone (PTH), albumin, uric acid, fasting glucose, total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and hemoglobin (Hgb), were measured before and after Ramadan fasting. P<0.05 was assumed significant.
Results: The study results demonstrated no significant deterioration in eGFR during Ramadan fasting (pre-Ramadan: 43.54±11.04 vs post-Ramadan: 44.28±11.51, p=0.063). Additionally, traditional risk factors for CKD progression, such as diabetes mellitus (DM), hypertension (HT), cardiovascular disease CVD, and age, did not show a significant association with eGFR changes during fasting (p>0.05). Furthermore, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARB) did not impact eGFR (0.084). Notably, Ramadan fasting led to improvements in metabolic parameters, such as fasting glucose and lipid profile, except for triglyceride levels (p<0.001).
Conclusion: The study results indicate that Ramadan fasting does not appear to have adverse effects on kidney function in individuals with CKD, although certain metabolic changes were observed.

Keywords : Ramadan fasting, chronic kidney disease, glomerular filtration rate, metabolic parameters, kidney function

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Article available in :
Volume 6, Issue 5, 2023
Page : 1016-1021
https://doi.org/10.32322/jhsm.1330331
Article Information
Received : 20 Tem 2023
Accepted : 04 Eyl 2023
Published : 28 Eyl 2023
Corresponding Author :

Mahmud İslam: Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey

[email protected]
Citation : İslam M. Impact of Ramadan fasting on eGFR in patients with late stage chronic kidney disease. J Health Sci Med. 2023;6(5):1016-1021.

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