JHSM

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Extra corporeal membrane oxygenation therapy in acute respiratory distress syndrome due to Coronavirus-2019 (COVID-19): a retrospective study
Aims: Extra corporeal membrane oxygenation (ECMO) has been used as a supportive treatment in ARDS due to COVID-19. Although different results have been reported in the literature regarding its efficacy, ECMO is recommended as a salvage therapy for severe forms of the disease after standard therapy fails. In our study,we aimed to evaluate the survival outcomes of patients supported with ECMO for COVID-19.
Methods: Our study was conducted by scanning the data of consecutive adult patients hospitalized in our intensive care unit due to COVID-19. The ECMO process was planned according to the Extracorporeal Life Support Organization (ELSO) and Berlin criteria.
Results: 51 patients hospitalized for acute respiratory failure due to COVID-19 were taken to ECMO. Demographic data of patients; 39 (76.5%) men and 12 (23.5%) women. 46 (90.2%) of the patients died. The mean intubation time before ECMO is 3.9 days, and the mean time for non-invasive mechanical ventilation is 5.8 days. The mean PaO2 value before ECMO was 79.09 mmHg, the mean PCO2 value was 63.62 mmHg and the mean PaO2/FiO2 ratio was 82.80.
Conclusion: The use of ECMO by considering prognostic factors and guidelines is seen as factors that increase the chance of success.Despite the fact that the patients were admitted to ECMO in accordance with the guidelines in our study, the high mortality rate suggests that there is a need for investigation of other supportive treatments and studies to reduce ECMO complications.


1. World Health Organization: Clinical management of severe acuterespirato ry infection when novel coronavirus (nCoV) infectionis suspected. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance
2. Crotti S, Bottino N, Spinelli E: Spontaneous breathing duringveno-venous extracorporeal membrane oxygenation. J ThoracDis. 2018;10(Suppl. 5):S661-669.
3. Kurihara C, Walter JM, Singer BD, et al. Extracorporeal membraneoxygenation can successfully support patients with severe acuterespiratory distress syndrome in lieu of mechanical ventilation.Crit Care Med. 2018;46(11):e1070-e1073.
4. Extracorporeal Life Support Organization (ELSO) report in 2018.Available from: https://www.elso.org/
5. Vieira J, Frakes M, Cohen J, Wilcox S. Extracorporealmembrane oxygenation in transport part 2: complications andtroubleshooting. Air Med J. 2020;39(2):124-132
6. Lim JKB, Qadri SK, Toh TSW, Lin CB, Mok YH, Lee JH.Extracorporeal membrane oxygenation for severe respiratoryfailure during respiratory epidemics and pandemics: a narrativereview. Ann Acad Med Singap. 2020;49(4):199-214.
7. Barbaro RP, MacLaren G, Boonstra PS, et al. Extracorporeal LifeSupport Organization. Extracorporeal membrane oxygenationsupport in COVID-19: an international cohort study of theExtracorporeal Life Support Organization registry. Lancet.2020;396(10257):1071-1078.
8. Combes A, Hajage D, Capellier G, et al. Extracorporeal membraneoxygenation for severe acute respiratory distress syndrome. NEngl J Med. 2018;378(21):1965-1975.
9. Schmidt M, Hajage D, Lebreton G, et al. Groupe de rechercheclinique en reanimation et soins intensifs du patient en insuffisancerespiratoire aigue (GRC-RESPIRE) Sorbonne Université;Paris-Sorbonne ECMO-COVID investigators. Extracorporealmembrane oxygenation for severe acute respiratory distresssyndrome associated with COVID-19: a retrospective cohortstudy. Lancet Respir Med. 2020;8(11):1121-1131.
10. Schmidt M, Pham T, Arcadipane A, et al. Mechanical ventilationmanagement during extracorporeal membrane oxygenation foracute respiratory distress syndrome. an international multicenterprospective cohort. Am J Respir Crit Care Med. 2019;200(8):1002-1012.
11. Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G.Hematologic, biochemical and immune biomarker abnormalitiesassociated with severe illness and mortality in coronavirusdisease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med.2020;58(7):1021-1028.
12. Terpos E, Ntanasis-Stathopoulos I, Elalamy I, et al. Hematologicalfindings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847.
13. Burrell AJC, Lubnow M, Enger TB, et al. The impact of venovenousextracorporeal membrane oxygenation on cytokine levels in patientswith severe acute respiratory distress syndrome: a prospective,observational study. Crit Care Resusc. 2017;19(Suppl 1):37-44.
14. Jacobs JP, Stammers AH, St Louis J, et al. Extracorporealmembrane oxygenation in the treatment of severe pulmonary andcardiac compromise in coronavirus disease 2019: experience with32 patients. ASAIO J. 2020;66(7):722-730.
15. Henry BM. COVID-19, ECMO, and lymphopenia: a word ofcaution. Lancet Respir Med. 2020;8(4):e24.
16. Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors ofmortality due to COVID-19 based on an analysis of data of 150patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-848.
17. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, MansonJJ. HLH Across Speciality Collaboration, UK. COVID-19: considercytokine storm syndromes and immunosuppression. Lancet.2020;395(10229):1033-1034.
18. Tran A, Fernando SM, Rochwerg B, et al. Prognostic factorsassociated with mortality among patients receiving venovenousextracorporeal membrane oxygenation for COVID-19: asystematic review and meta-analysis. Lancet Respir Med. 2022:S2213-2600(22)00296-X.
19. Uysal E, Seğmen F, Ulubaşoğlu P, Zengin E.N, Erdem D. Theprogress of chronic renal disease patients followed by the diagnosisof COVID-19 in ICU. J Health Sci Med. 2022;5(5):1447-1452
Volume 6, Issue 5, 2023
Page : 1059-1063
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