JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The relationship between serum soluble ACE 2 protein level and the clinical course of COVID-19 disease
Abstract
Aims: The angiotensin converting enzyme 2 (ACE 2) molecule, which mediates the entry of the virus into the cell, plays a very important role in the pathogenesis of COVID-19 disease. However, its effect on prognosis has not been fully explained. In this study, it was aimed to investigate the relationship between soluble ACE 2 (sACE 2) levels in the blood and the course of the disease.
Methods: sACE 2 levels at 0, 3 and 5 days were measured in patients with mild, moderate and severe COVID-19 pneumonia who were hospitalized between March 15, 2020 and August 30, 2020.
Results: 69 patients, 35 (51.5%) female and 34 (49.3%) male, with a mean age of 64.3±2.1 were included in the study. 42.0% of the patients had mild, 30.4% moderate, 27.5% severe pneumonia. Clinical follow-up of 7 patients resulted in death. There was no statistically significant difference between sACE 2 levels and gender, severity of pneumonia, initial hospitalization, presence of intubation and mortality.
Conclusion: sACE 2 levels were not associated with disease severity and inflammatory markers. Studies in larger patient populations are needed to explain the relationship between sACE 2 activity and SARS-CoV-2 infection and to develop new treatment strategies.

Keywords : COVID-19, angiotensin converting enzyme 2, prognosis

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Article available in :
Volume 6, Issue 5, 2023
Page : 1142-1146
https://doi.org/10.32322/jhsm.1343953
Article Information
Received : 15 Ağu 2023
Accepted : 20 Eyl 2023
Published : 28 Eyl 2023
Corresponding Author :

Derya Korkmaz: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey

[email protected]
Citation : Korkmaz D, Köken T, Koca HB, Orhan S, Demirtürk N. The relationship between serum soluble ACE 2 protein level and the clinical course of COVID-19 disease. J Health Sci Med. 2023;6(5):1142-1146.

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