JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Distribution of ABO and Rh blood groups in gynecological cancer cases
Abstract
Aims: To investigate the relationship between blood type and gynecological cancers (ovarian, endometrial, and cervical).
Methods: In the study, between 2017 and 2022, 457 patient files who underwent surgery for gynecological cancer at İstanbul Prof. Dr. Cemil Taşçıoğlu City Hospital were reviewed. Seventy-eight of these files were excluded from the study due to missing data. Out of the remaining files, 379 were considered suitable for the study. Twenty-five of these were further excluded due to being cases of other gynecological cancers. A total of 354 patients were included in the study (n=354). Participants' sociodemographic data such as age and gender, cancer type, and blood groups (ABO-Rh) were retrospectively collected from patient records and the hospital automation system. Cases with missing data or inaccessible sociodemographic records were excluded from the study. The study was planned retrospectively and observationally. Gynecological cancers were examined in the three most common groups: ovarian cancer, endometrial cancer, and cervical cancer. The patients' blood group, Rh status, and pathology reports were analyzed. Based on the pathological diagnosis, three groups were initially formed, and below them, Rh and blood group status were noted. The blood group and Rh status in cancer groups were first presented in numbers and then calculated as percentages.
Results: The AB+ ratio in cervical cancers was statistically significantly higher compared to the reference article and endometrial cancers (p=0.021, p=0.049).
Conclusion: There are studies indicating a significant relationship between blood groups and various diseases. The expression of blood group antigens on blood cells and other epithelial surfaces acting as receptors or signal transducers contributes to these findings. The possibility of ABO antigens serving as receptors in tumor structures caused by infections, such as cervical cancer, should not be overlooked. In this regard, the significantly higher prevalence of cervical cancer in individuals with AB Rh (+) blood type, carrying A, B, and Rh antigens, can be explained concerning the population.

Keywords : Gynecological cancers, blood group, cervical cancers

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1. Weissinger M, Kommoss S, Jacoby J, et al. Multiparametric dual-time-point [18F] FDG PET/MRI for lymph node staging inpatients with untreated FIGO I/II cervical carcinoma. J Clin Med.2022;11(17):4943.
2. Wright JD, Matsuo K, Huang Y, et al. Prognostic performanceof the 2018 International Federation of Gynecology andObstetrics Cervical Cancer Staging Guidelines. Obstet Gynecol.2019;134(1):49.
3. Berek JS, Matias-Guiu X, Creutzberg C, et al. FIGO staging ofendometrial cancer: 2023. Int J Gynaecol Obstet. 2023;162:383.
4. Torre LA, Trabert B, DeSantis CE, et al. Ovarian cancer statistics,2018. CA Cancer J Clin. 2018;68(4):284.
5. Şahin F, Aydın E, Öcal EU, et al. Evaluation of colposcopy and LEEPresults performed in gynecology and gynecological oncologysurgery services. Eur J Gynaecol Oncol. 2024. doi:10.22514/ejgo.2023.071
6. Yamamoto F, Cid E, Yamamoto M, et al. ABO research in themodern genomics era. Transfusion Med Rev. 2012;26(2):103-118.
7. Canan E. İstanbul ilinde ABO ve Rh kan grupları dağılımınınanalizi. Dicle Tıp Derg. 2019;46(2):241-246.
8. Lin S, Cao Y, Zhu K, et al. Identification of a novel prognosticsignature based on N-linked glycosylation and its correlationwith immunotherapy response in hepatocellular carcinoma. JHepatocell Carcinoma. 2023;10:1749-1765.
9. Thakur SK, Sompal S, Dinesh Kumar N, et al. Link betweenhuman ABO blood groups with diseases influencing blood donorsand recipients frequency at RBTC, Delhi, India. Bioinformation.2023;19(5):576-581.
10. Cozzi GD, Levinson RT, Toole H, et al. Blood type, ABOgenetic variants, and ovarian cancer survival. PLoS One.2017;12(4):e0175119.
11. Marinaccio M, Traversa A, Carioggia E, et al. Blood groups ofthe ABO system and survival in gynecological tumors. MinervaGinecol. 1995;47(3):69-76.
12. Kai LJ, Raju K, Lingaiah HKM, et al. Importance of blood typeand social factors in carcinoma cervix in a semi-urban populationin India. Asian Pac J Cancer Prev. 2013;14(8):4811-4814.
13. Fotra R, Upma U, Gupta S, et al. Association of ABO and Rh bloodgroups with the carcinoma of the cervix with special reference toJammu region. Biosci Biotech Res Asia. 2011;8(1):313-316.
14. Hanprasertpong J, Jiamset I. Atjimakul T. Prognostic value ofABO blood group in patients with early stage cervical cancertreated with radical hysterectomy with pelvic node dissection.Tumor Biol. 2016;37(6):7421-7430
15. Tyagi SP, Tiagi GK, Pradhan S. ABO blood grops in relation tocancer cervix. Indian J Med Sci. 1967;21:611-615.
16. Vaillant AJ, Bazuaye P, McFarlane-Anderson N, et al. Associationbetween ABO blood type and cervical dysplasia/carcinoma inJamaican women. Brit J Med Med Res. 2013;28;3(4):2017-2021.
17. Razzaghi N, Seraj H, Heydari K, et al. ABO blood groupsassociations with ovarian cancer: a systematic review and meta-analysis. Indian J Gynecol Oncolog. 2020;18(4):112.
18. Seebacher V, Polterauer S, Reinthaller A, et al. AB0 blood groupsand rhesus factor expression as prognostic parameters in patientswith epithelial ovarian cancer - a retrospective multicenter study.BMC Cancer. 2018;18(1):447.
19. Song Q, Wu JZ, Wang S, Chen ZB. ABO blood type is anindependent prognostic factor in ovarian cancer patients. JCancer. 2019;10(26):6754-6760.
20. Xu WH, Zheng W, Xiang YB, et al. ABO blood type is associatedwith endometrial cancer risk in Chinese women. Chin J Cancer.2011;30(11):766-771.
21. Mandato VD, Torricelli F, Mastrofilippo V, et al. Prognostic impactof ABO blood group on type I endometrial cancer patients- resultsfrom our own and other studies. J Cancer. 2017;8(14):2828-2835.
22. Gitas G, Proppe L, Alkatout I, et al. Is ABO blood group a riskor prognostic factor for patients with endometrioid endometrialcancer? a retrospective analysis in Germany. Blood Transfus.2020;18(6):465-470.
23. Şahin F, Odacılar AŞ, Günkaya OS, et al. Is neutrophil lymphocyteratio magic or not? J Health Sci Med. 2023;6(3):618-622.
24. Raev SA, Raque M, Kick MK, Saif LJ, Vlasova AN. Differentialtranscriptome response following infection of porcine ilealenteroids with species A and C rotaviruses. Virol J. 2023;20(1):238.
25. Teuwen LA, Geldhof V, Pasut A, et al. COVID-19: vascular systemreleased. Nature Rev Immunol. 2020;20(7):389-391.
26. Abegaz SB. Human ABO blood groups and their associations withdifferent diseases. Biomed Res Int. 2021;2021:6629060.
Article available in :
Volume 7, Issue 1, 2024
Page : 126-131
https://doi.org/10.32322/jhsm.1404257
Article Information
Received : 14 Ara 2023
Accepted : 10 Oca 2024
Published : 15 Oca 2024
Corresponding Author :

Ramazan Adan: Department of Obstetrics and Gynecology, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, Turkey

[email protected]
Citation : Adan R, Mihmanlı V. Distribution of ABO and Rh blood groups in gynecological cancer cases. J Health Sci Med. 2024;7(1):126-131.

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