JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Association between pancreatic lipase levels and coronavirus disease-2019
Abstract
Aims: Elevated pancreatic enzyme can be observed in the course of coronavirus disease-2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we aimed to determine the frequency of lipase elevation in the course of COVID-19 and examine its effect on disease outcomes.
Methods: Of 42742 patients with the positivity of SARS-CoV-2 reverse transcriptase-polymerase chain reaction test (RT-PCR), 3167 undergoing lipase tests were included. The relationship between patients’ clinical features, development of acute pancreatitis (AP), and mortality rates was investigated.
Results: Higher lipase levels than normal limits were found in 399 (12.6%) patients. Lipase levels were three times higher than the normal limit in 119 (3.8%) patients; compared to the rest of the patients, patients’ age (62.8±17.9 vs 52.1±17.9 years, p<0.001), and rates of male patients (58% vs 45%, p=0.006) and mortality (17.6% vs 8%, p=0.001 respectively) were higher. Thirty-two (1.01%) patients were diagnosed with acute pancreatitis (AP). As lipase levels elevated, hospitalization (p<0.001) and requirement for intensive care unit (p=0.002) also increased. A total of 264 (8.3%) patients died, and mortality rates were higher in males (11% vs 6%, p<0.001). The dead were older (72.0±12.3 years vs 50.7±17.4 years, p<0.001). There was a linear positive correlation between patients’ age (p<0.001), lipase levels (p<0.001), and mortality. Mortality was increased among men and in the presence of AP (p<0.001).
Conclusion: Pancreatic enzyme levels should be measured in the course of COVID-19 due to increased mortality in patients of advanced age, males with AP, and high lipase levels.

Keywords : Coronavirus disease 2019, COVID-19, lipase, pancreas, pancreatitis, SARS-CoV-2

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Article available in :
Volume 7, Issue 2, 2024
Page : 185-191
https://doi.org/10.32322/jhsm.1412910
Article Information
Received : 01 Oca 2024
Accepted : 10 Mar 2024
Published : 25 Mar 2024
Corresponding Author :

Canan Akkuş: Department of Internal Medicine, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Akkuş C, Kayhan S, Yılmaz H, Demirci H, Karanlık İ, Duran C. Association between pancreatic lipase levels and coronavirus disease-2019. J Health Sci Med. 2024;7(2):185-191.

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