JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

ISSN: Active
eISSN: 2636-8579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
Protective effects of curcumin and quercetin in studies on cancer: a meta-analysis study
Abstract
Aims: Polyphenolic chemicals, such as quercetin and curcumin have anti-cancer properties due to their antioxidant and anti-inflammatory properties. Quercetin and curcumin aids in detoxification by boosting enzyme function and eliminating free radicals. We aimed to conduct a detailed meta-analysis of research articles reporting the protective effects of curcumin and quercetin in cancer studies.
Methods: The study was selected all studies over time carried out to date within the framework of our concept ,using various medical subject headings and databases like Elsevier, National Library of Frontiers, ResearchGate, Scopus Medicine, and Google Scholar. PRISMA guidelines was performed. The data management system played a significant role in locating and evaluating relevant articles, ensuring the accuracy and precision of the findings.
Results: From a total of 85 articles accessed in this analysis, 4 studies on quercetin and 3 studies on curcumin were included. The analyzed studies show that quercetin and curcumin have anti-cancer benefits through various cellular pathways. Quercetin inhibits Twist in breast cancer cells, while curcumin reduces Akt/mTOR cellular signaling, enhances Bax expression, and triggers cell death. It also prevents cell growth in human lung cancer cells and bladder cancer. Curcumin control reactive oxygen species levels, inhibit cancer cell proliferation, and stimulate apoptotic pathways. They also influence cancer development by altering cellular signaling pathways and affecting non-coding RNAs.
Conclusion: Our meta-analysis reports that quercetin and curcumin have the potential to be used in the treatment and prevention of cancer, it may be useful to investigate their synergistic effects.

Keywords : Antioxidants, cancer, curcumin, functional foods, quercetin

Download Article


1. Abbas M, Saeed F, Anjum FM, et al. Natural polyphenols: an overview. Int J Food Prop. 2017;20(8):1689-1699. doi: 10.1080/10942912.2016.1220393
2. Mancini-Filho J. Bioavailability of phenolic compounds in food and their properties in cellular protection. Bioequiv Bioavailab Int J. 2020;4(1):000145. doi: 10.23880/beba-16000145
3. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270-278. doi: 10.4161/oxim.2.5.9498
4. Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45(4):287-306. doi: 10.1080/1040869059096
5. Slika H, Mansour H, Wehbe N, et al. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomed Pharmacother. 2022;146:112442. doi: 10.1016/j.biopha.2021.112442
6. León-González AJ, Auger C, Schini-Kerth VB. Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy. Biochem Pharmacol. 2015; 98(3):371-380. doi: 10.1016/j.bcp.2015.07.017
7. Cione E, Torre C La, Cannataro R, Caroleo MC, Plastina P, Gallelli L. Quercetin, epigallocatechin gallate, curcumin, and resveratrol: from dietary sources to human microRNA modulation. Molecules. 2020;25(1):63. doi: 10.3390/molecules25010063
8. Batiha GE, Beshbishy AM, Ikram M, et al. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020; 9(3):374. doi: 10.3390/foods9030374
9. Lakhanpal P, Rai DK. Quercetin: a versatile flavonoid. Int J Med Update. 2007;2(2):22-37. doi: 10.4314/ijmu.v2i2.39851
10. Tang SM, Deng XT, Zhou J, Li QP, Ge XX, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacother. 2020;121:109604. doi: 10.1016/j.biopha.2019.109604
11. Shafabakhsh R, Asemi Z. Quercetin: a natural compound for ovarian cancer treatment. J Ovarian Res. 2019;12(1):55. doi: 10.1186/s13048-019-0530-4
12. Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - a review. J Tradit Complement Med. 2017;7(2):205-233. doi: 10.1016/j.jtcme.2016.05.005
13. Katsuyama Y, Kita T, Funa N, Horinouchi S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J Biologic Chem. 2009;284(17):11160-11170. doi: 10.1074/jbc.M900070200
14. Naama JH, Alwan GH, Obayes HR, et al. Curcuminoids as antioxidants and theoretical study of stability of curcumin isomers in gaseous state. Res Chemic Intermediat. 2013;39(9):4047-4059. doi: 10.1007/s11164-012-0921-2
15. Cháirez-Ramírez MH, de la Cruz-López KG, García-Carrancá A. Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways. Front Pharmacol. 2021;12:710304. doi: 10.3389/fphar.2021.710304
16. Wang H, Zhang K, Liu J, et al. Curcumin regulates cancer progression: focus on ncRNAs and molecular signaling pathways. Front Oncol. 2021;11:660712. doi: 10.3389/fonc.2021.660712
17. Khan H, Reale M, Ullah H, et al. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions. Biotechnol Adv. 2020;38:107385. doi: 10.1016/j.biotechadv.2019.04.007
18. Hasan AA, Tatarskiy V, Kalinina E. Synthetic pathways and the therapeutic potential of quercetin and curcumin. Int J Mol Sci. 2022;23(22):14413. doi: 10.3390/ijms232214413
19. Desmoulin A, Joly E, Tran P, Derancourt C, Bertolotti A. Methodological quality of systematic reviews of the local management of anogenital warts: a systematic review using AMSTAR II, ROBIS and PRISMA. Sex Transm Infect. 2023; 99(5):345-347. doi: 10.1136/sextrans-2023-055796
20. Ranganathan S, Halagowder D, Sivasithambaram ND. Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells. PLoS One. 2015;10(10):e0141370. doi: 10.1371/journal.pone.0141370
21. Hu S, Xu Y, Meng L, Huang L, Sun H. Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Exp Ther Med. 2018;16(2):1266-1272. doi: 10.3892/etm.2018.6345
22. Catanzaro D, Ragazzi E, Vianello C, Caparrotta L, Montopoli M. Effect of quercetin on cell cycle and cyclin expression in ovarian carcinoma and osteosarcoma cell lines. Nat Prod Commun. 2015;10(8):1365-1368. doi: 10.1177/1934578x1501000813
23. Yu Z, Wan Y, Liu Y, Yang J, Li L, Zhang W. Curcumin induced apoptosis via PI3K/Akt-signalling pathways in SKOV3 cells. Pharm Biol. 2016;54(10):2026-2032. doi: 10.3109/13880209.2016.1139601
24. Yang L, Liu Y, Wang M, et al. Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Mol Med Rep. 2016;14(5):4559-4566. doi: 10.3892/mmr.2016.5818
25. Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. PLoS One. 2013;8(2):e57218. doi: 10.1371/journal.pone.0057218
26. Mo F, Xiao Y, Zeng H, et al. Curcumin-induced global profiling of transcriptomes in small cell lung cancer cells. Front Cell Dev Biol. 2021;8:588299. doi: 10.3389/fcell.2020.588299
27. Tsai TF, Hwang TIS, Lin JF, et al. Suppression of quercetin-induced autophagy enhances cytotoxicity through elevating apoptotic cell death in human bladder cancer cells. Urol Sci. 2019;30(2):58-66. doi: 10.4103/UROS.UROS_22_18
28. Zhaorigetu, Farrag IM, Belal A, et al. Antiproliferative, apoptotic effects and suppression of oxidative stress of quercetin against induced toxicity in lung cancer cells of rats: In vitro and in vivo study. J Cancer. 2021;12(17):5249. doi: 10.7150/jca.52088
29. Tsiailanis AD, Renziehausen A, Kiriakidi S, et al. Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid. Free Radic Biol Med. 2020;160:391-402. doi: 10.1016/j.freeradbiomed.2020.08.007
30. Luo SM, Wu YP, Huang LC, Huang SM, Hueng DY. The anti-cancer effect of four curcumin analogues on human glioma cells. Onco Targets Ther. 2021;14:4345-4359. doi: 10.2147/OTT.S313961
31. Zhou H, Ning Y, Zeng G, Zhou C, Ding X. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncol Rep. 2021;45(4):11. doi: 10.3892/or.2021.7962
32. Grillone K, Riillo C, Scionti F, et al. Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter”. J Exper Clin Cancer Res. 2020;39(1):117. doi: 10.1186/s13046-020-01622-x
33. Yi J, Li S, Wang C, et al. Potential applications of polyphenols on main ncRNAs regulations as novel therapeutic strategy for cancer. Biomed Pharmacother. 2019;113:108703. doi: 10.1016/j.biopha.2019.108703
34. Liu H, Lei C, He Q, Pan Z, Xiao D, Tao Y. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018;17(1):64. doi: 10.1186/s12943-018-0765-5
35. Winkle M, El-Daly SM, Fabbri M, Calin GA. Noncoding RNA therapeutics — challenges and potential solutions. Nat Rev Drug Discov. 2021;20(8):629-651. doi: 10.1038/s41573-021-00219-z
36. Nwaeburu CC, Bauer N, Zhao Z, et al. Up-regulation of microRNA Let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget. 2016;7(36):58367-58380. doi: 10.18632/oncotarget.11122
37. Sohn EJ, Bak KM, Nam YK, Park HT. Upregulation of microRNA 344a-3p is involved in curcumin induced apoptosis in RT4 schwannoma cells. Cancer Cell Int. 2018;18(1):199. doi: 10.1186/s12935-018-0693-x
38. Pan L, Sha J, Lin W, Wang Y, Bian T. Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis. Exp Ther Med. 2021;22(3):969. doi: 10.3892/etm.2021.10401
39. Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X. Effects of quercetin on the efficacy of various chemotherapeutic drugs in cervical cancer cells. Drug Des Devel Ther. 2021;15:577-588. doi: 10.2147/DDDT.S291865
40. Shen H, Shen J, Pan H, et al. Curcumin analog B14 has high bioavailability and enhances the effect of anti-breast cancer cells in vitro and in vivo. Cancer Sci. 2021;112(2):815-827. doi: 10.1111/cas.14770
41. Suh DK, Lee EJ, Kim HC, Kim JH. Induction of G1/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. Arch Pharm Res. 2010;33(5):781-785. doi: 10.1007/s12272-010-0519-4
Article available in :
Volume 7, Issue 3, 2024
Page : 314-320
https://doi.org/10.32322/jhsm.1454820
Article Information
Received : 18 Mar 2024
Accepted : 11 May 2024
Published : 27 May 2024
Corresponding Author :

Yahya Altınkaynak: Department of Medical Services and Techniques, Ardahan Vocational School of Health, Ardahan, Turkiye

[email protected]
Citation : Altınkaynak Y, Akcan Altınkaynak B. Protective effects of curcumin and quercetin in studies on cancer: a meta-analysis study. J Health Sci Med. 2024;7(3):314-320.

Read: 299
Cited: 0
Download : 83
_Footer