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Journal of Health Sciences and Medicine

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Original Article
The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia
Abstract
Aims: The aim of this study is to examine the alterations in various serum parameters within the circulatory system throughout the first trimester and assess their efficacy in identifying pre-eclampsia at an early stage.
Methods: This retrospective analysis undertook an examination of the medical records pertaining to 225 pregnancies that met the eligibility criteria at a tertiary referral center, spanning the years 2018 to 2021. Furthermore, an examination of laboratory parameters during the first trimester was performed, which included neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammation index, systemic inflammation response index, pan-immune inflammation value, AST-to-platelet ratio index, delta neutrophil index, and prognostic nutritional index (PNI). A receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for inflammatory and nutritional biomarkers to predict early- onset pre-eclampsia.
Results: The group of individuals with early-onset pre-eclampsia displayed notably elevated levels of neutrophil, lymphocyte, PCT, MPV, ALT, and creatinine, while displaying significantly reduced levels of albumin, bilirubin, PLR, MLR, and PNI (p<0.05, for all). The statistical significance of the area under the curve for PNI, albumin, PLR, MLR, and bilirubin values was observed to be greater than 0.5 (p<0.05, for all).
Conclusion: This article is the first to examine the efficacy of the first trimester PNI value in early detection of pre-eclampsia patients. According to this study, PNI, albumin, PLR, MLR, and bilirubin show potential as useful indicators for predicting the likelihood of developing pre-eclampsia at an early stage in the first trimester.

Keywords : Serum markers, pregnancy, first trimester, high-risk, pre-eclampsia

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Article available in :
Volume 7, Issue 4, 2024
Page : 451-458
https://doi.org/10.32322/jhsm.1500190
Article Information
Received : 12 Haz 2024
Accepted : 19 Tem 2024
Published : 30 Tem 2024
Corresponding Author :

Büşra Demir Çendek: Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Demir Çendek B, Ağbal T, Akay A, Can İbanoğlu M, Engin Üstün Y. The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia. J Health Sci Med. 2024;7(4):451-458.

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