JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Does intranasal Demodex infestation play a role in allergic rhinitis?
Abstract
Aims: The aim of this study is to evaluate the prevalence of Demodex mites in the intranasal follicles of patients with allergic rhinitis and investigate their potential role in the etiology of allergic rhinitis.
Methods: The study involved 50 patients diagnosed with allergic rhinitis and 50 healthy controls matched for age and gender. The severity of the disease was evaluated using the Score for Allergic Rhinitis and the Total Nasal Symptom Score (TNSS). To evaluate the presence of Demodex in nasal follicles, a total of 8 terminal follicles, 4 from each of the right and left nasal vestibules, were epilated using sterile forceps. The samples were examined under a light microscope at 10x, 40x, and 100x magnification by two dermatologists.
Results: Demodex mites were found in the intranasal follicles of 3 (6%) individuals from the healthy control group. Intranasal Demodex mites were found in 3 (6%) patients with allergic rhinitis, showing no statistically significant difference between the two groups (p=1). The mean total nasal symptom score was 7.66±1.52 in the 3 allergic rhinitis patients with Demodex positivity, and 7.61±1.13 in the 47 patients without Demodex infestation, with no statistically significant difference between the two groups (p>0.05). No significant correlation was observed between Demodex positivity, disease severity, and TNSS in patients with allergic rhinitis (p>0.05).
Conclusion: Based on our study results, we think that intranasal antiparasitic treatments may be unnecessary in patients with allergic rhinitis.

Keywords : Demodex, allergic rhinitis, TNSS

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1. Liu Y, Sha J, Meng C, Zhu D. Mechanism of lower airway hyperresponsiveness induced by allergic rhinitis. J Immunol Res. 2022;2022:4351345. doi:10.1155/2022/4351345
2. Wang CS, Wang XD, Zhang L. An introduction to allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;53(10):798-800. doi:10.3760/cma.j.issn.1673-0860.2018.10.017
3. Katelaris CH, Lee BW, Potter PC, et al. Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. Clin Exp Allergy. 2012;42(2):186-207. doi:10. 1111/j.1365-2222.2011.03891.x
4. Tidke M, Borghare PT, Pardhekar P, Nasre Y, Gomase K, Chaudhary M. Recent advances in allergic rhinitis: a narrative review. Cureus. 2024;16(9):e68607. doi:10.7759/cureus.68607
5. Moran EM, Foley R, Powell FC. Demodex and rosacea revisited. Clin Dermatol. 2017;35(2):195-200. doi:10.1016/j.clindermatol. 2016.10.014
6. Palopoli MF, Fergus DJ, Minot S, et al. Global divergence of the human follicle mite Demodex folliculorum: persistent associations between host ancestry and mite lineages. Proc Natl Acad Sci USA. 2015;112(52):15958-63. doi:10.1073/pnas.1512609112
7. Arli C, Ozsan M, Gurkan E, Aycan Kaya O, Kokacya S. The incidence of Demodex folliculorum in the combination of allergic rhinitis and diabetes mellitus. Iran J Parasitol. 2019;14(3):459-464.
8. Yengil E, Cevik C, Kaya OA, Taner M, Akkoca AN, Ozer C. Relationship between Demodex folliculorum and allergic rhinitis in adults. Acta Med Mediterr. 2014;30:27-31.
9. Canonica GW, Mullol J, Pradalier A, Didier A. Patient perceptions of allergic rhinitis and quality of life: findings from a survey conducted in europe and the United States. World Allergy Organ J. 2008;1(9):138-44. doi:10.1097/WOX.0b013e3181865faf
10. Bevins CL, Liu FT. Rosacea: skin innate immunity gone awry? Nat Med. 2007;13(8):904-906. doi:10.1038/nm0807-904
11. Aktaş Karabay E, Aksu Çerman A. Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis. An Bras Dermatol. 2020;95(2):187-193. doi:10.1016/j.abd.2019.08.023
12. Sharma YK, Gupta A. Human Demodex mite: the versatile mite of dermatological importance. Indian J Dermatol. 2014;59(3):302. doi:10.4103/0019-5154.131416
13. Rusiecka-Ziólkowska J, Nokiel M, Fleischer M. Demodex-an old pathogen or a new one? Adv Clin Exp Med. 2014;23(2):295-298. doi:10.17219/acem/37081
14. Liu J, Sheha H, Tseng SC. Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol. 2010;10(5):505-10. doi:10.1097/ACI.0b013e32833df9f4
Article available in :
Volume 8, Issue 1, 2025
Page : 1-3
https://doi.org/10.32322/jhsm.1546310
Article Information
Received : 10 Eyl 2024
Accepted : 21 Eki 2024
Published : 12 Oca 2025
Corresponding Author :

İlkay Can: Department of Dermatology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkiye

[email protected]
Citation : Can İ, Şapaloğlu NC, Keleş H, Göçer Gürok N, Sakallıoğlu Ö, Öztürk S. Does intranasal Demodex infestation play a role in allergic rhinitis? J Health Sci Med. 2025;8(1):1-3.

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