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Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Relationship between triglyceride-glucose index and intravenous thrombolysis outcomes for acute ischemic stroke
Abstract
Aims: The aim of this study was to investigate the effect of triglyceride glucose index, a marker of insulin resistance, on early neurological deterioration (END), development of intracerebral hemorrhage and hemorrhagic transformation and mortality in patients receiving intravenous thrombolytic therapy for acute ischemic stroke.
Methods: This retrospective study included 71 patients with acute ischemic stroke who received intravenous tissue plasminogen activator. Demographic data, clinical and radiological findings, fasting glucose and lipid profile, END, hemorrhage development and mortality rates were analyzed. We also calculated the triglyceride glucose (TyG) index and examined its correlation with early neurological deterioration, hemorrhage development and mortality.
Results: The median age was 74 years (41-88), with a female predominance of 54.9%. The incidence of intracerebral hemorrhage was 9.6%, while END occurred in 39.6% of cases, and the 30-day mortality rate was 28.2%. The mean TyG index was 7.8 (2.8-27.6). The receiver operating characteristic curve analysis indicated that the TyG index predicted mortality with an area under the curve of 84.4%, a sensitivity of 85%, and a specificity of 82.35% in patients with a TyG index above 10.01 (p<0.01). According to univariate analyse, the admission NIHSS score was associated with a 1.46-fold increase in the odds of mortality (odds ratio [OR]: 1.459), while a TyG index greater than 10.01 was associated with a 1763.9-fold increase in mortality risk (OR: 1763.9) (p=0.005; p=0.009, respectively). Patients with higher TyG index also exhibited significantly increased rates of mortality and END (p<0.001 for both). There was no association between development of hemorrhage and TyG index (p>0.05).
Conclusion: This study supports that a high TyG index is associated with END and mortality but not with the development of hemorrhage. Multicenter studies with larger sample size are needed.

Keywords : Triglyceride glucose index, insulin resistance, intravenous thrombolytic therapy, acute ischemic stroke, hemorrhagic transformation

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Article available in :
Volume 8, Issue 1, 2025
Page : 52-56
https://doi.org/10.32322/jhsm.1543216
Article Information
Received : 03 Eyl 2024
Accepted : 29 Kas 2024
Published : 12 Oca 2025
Corresponding Author :

Selcen Duran: Department of Neurology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir, Turkiye

[email protected]
Citation : Duran S, Yetiş A. Relationship between triglyceride-glucose index and intravenous thrombolysis outcomes for acute ischemic stroke. J Health Sci Med. 2025;8(1):52-56.

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