JHSM
Journal of Health Sciences and Medicine

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Original Article
Changes in body composition and muscle strength in girls with idiopathic central precocious puberty during gonadotropin-releasing hormone agonist therapy
Abstract
Aims: Our objective is to explore changes in body fat distribution and muscle strength among a cohort of girls with idiopathic central precocious puberty (ICPP) undergoing the gonadotropin-releasing hormone analogs (GnRHa) therapy.
Methods: A total of 50 patients who were newly diagnosed with ICPP and treated with GnRHa were included in the study. Patients were investigated at baseline, 6th months and 12th months.
Results: Body-mass index (BMI) standard deviation score (SDS) was similar throughout the treatment duration. The percentage of body fat (PBF) increased from 24.2±5.1% at the beginning to 26.3±5.3% at the 6th month and to 27.7±5.43% at the 12th month (p<0.001). While lean body mass (LBM) increased during the treatment duration (p<0.001), there was a decrease in the LBM percentage in both the 6th month and 12th month (p=0.001, p=0.005). The change in PBF between 0 and 12 months was significantly higher in the group with PBF<97th percentile (p), with a median of 2.3 (3.3)%, compared to a median of 0.5 (0.5)% in the group with PBF>97th p (p=0.005).
Conclusion: Over the one-year duration of GnRHa treatment, no increase was observed in BMI SDS. While PBF increased, a decrease was noted in LBM percentage. Despite the decrease in LBM percentage, since LBM increased over the course of treatment, an increase in muscle strength was observed under GnRHa therapy. Additionally, the alteration in PBF during GnRHa treatment exhibited variations based on the initial PBF status.

Keywords : Central precocious puberty, GnRHa therapy, body composition, lean body mass, muscle strength

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Article available in :
Volume 8, Issue 1, 2025
Page : 63-69
https://doi.org/10.32322/jhsm.1557045
Article Information
Received : 27 Eyl 2024
Accepted : 02 Ara 2024
Published : 12 Oca 2025
Corresponding Author :

Zeynep Donbaloğlu: Department of Pediatric Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, Turkiye

[email protected]
Citation : Donbaloğlu Z, Singin B, Barsal Çetiner E, et al. Changes in body composition and muscle strength in girls with idiopathic central precocious puberty during gonadotropin-releasing hormone agonist therapy. J Health Sci Med. 2025;8(1):63-69.

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