JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
C-reactive protein/albumin ratio as a prognostic biomarker in myasthenia gravis
Abstract
Aims: Limited research has explored novel inflammatory targets in myasthenia gravis (MG). This study aimed to investigate the role of the C-reactive protein (CRP)/albumin ratio (CAR) in disease activity and prognosis in MG patients.
Methods: CRP, albumin, and CAR levels were compared between MG patients and healthy controls. The relationships of these parameters with MG activities of daily living (MG-ADL) scores and mortality were examined.
Results: Sixty-six patients and 51 controls participated. CRP and CAR levels were significantly higher in the patient group (p=0.002, 0.003). No significant difference was found in albumin levels (p=0.154). A positive correlation was observed between the MG-ADL stage and both CRP and CAR levels (p=0.000 for both), with these markers increasing as MG-ADL worsened. A negative correlation was found between the MG-ADL stage and albumin (p=0.003). CRP, CAR, and albumin levels were significantly associated with mortality (p=0.000, 0.000, 0.005).
Conclusion: Elevated CRP and CAR levels in MG patients suggest acute inflammation contributing to clinical decline. Albumin’s decrease with worsening MG-ADL suggests its value as a prognostic marker rather than a diagnostic. CAR proved to be a stronger marker than albumin for disease diagnosis, severity monitoring, and mortality prediction. Our findings could help illuminate inflammatory mechanisms in MG and other neuromuscular diseases.

Keywords : Myasthenia gravis, C-reactive protein, albumin

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Article available in :
Volume 8, Issue 1, 2025
Page : 126-131
https://doi.org/10.32322/jhsm.1600622
Article Information
Received : 12 Ara 2024
Accepted : 03 Oca 2025
Published : 12 Oca 2025
Corresponding Author :

Esen Çiçekli: Department of Neurology, Sakarya Akyazı State Hospital, Sakarya, Turkiye

[email protected]
Citation : Çiçekli E, Kotan D. C-reactive protein/albumin ratio as a prognostic biomarker in myasthenia gravis. J Health Sci Med. 2025;8(1):126-131.

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