JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Evaluation of intravenous iloprost use in critically ill pediatric patients: a single-center experience
Abstract
Aims: Iloprost is a prostacyclin analog that has vasodilatation properties at the systemic level, inhibiting platelet aggregation and adhesion and triggering angiogenesis. Our experience with intravenous (IV) administration of iloprost as a vasodilator in pediatric intensive care units is limited. The present study investigates the characteristics of patients subjected to IV iloprost therapy and their response to treatment.
Methods: A 15-month period, all patients who received IV iloprost treatment were included. Data including age, gender, reason for hospitalization, cause of vascular damage, affected vessel, iloprost dosage, treatment duration, necessity of surgery, and occurrence of treatment-related complications were retrieved from retrospective patient files.
Results: During the study, IV ten patients receiving iloprost treatment were examined. The starting dose of the drug was 0.5 ng/kg/min in all patients, and the initial dose was continued in seven patients. Duration of iloprost use was 17.8±10.8 (min 1, max 28) days. 50% (n=5) of the reasons for hospitalization were non-traumatic reasons. Amputation was performed in three patients (30%). In the clinical classification of those with damage to the extremities, there were four patients in stage 1 (44.5%), two patients in stage IIa (22.2%), and three patients in stage IIb (33.3%). Amputation was applied to three patients in stage IIb, and this is the patient group where the dose was started at a dose of 0.5 ng/kg/min and the dose was increased.
Conclusion: Intravenous iloprost treatment is a safe therapeutic option with minimal side effects, beneficial for preventing hypoxia and tissue cellular damage in cases of vascular injury.

Keywords : Child, iloprost, pediatric intensive care, vasodilation

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Article available in :
Volume 8, Issue 2, 2025
Page : 249-253
https://doi.org/10.32322/jhsm.1576395
Article Information
Received : 30 Eki 2024
Accepted : 06 Şub 2025
Published : 21 Mar 2025
Corresponding Author :

Merve Mısırlıoğlu: Department of Pediatric Intensive Care, Faculty of Medicine, Mersin University, Mersin, Turkiye

[email protected]
Citation : Mısırlıoğlu M, Alakaya M, Arslanköylü AE, Bilgiç A. Evaluation of intravenous iloprost use in critically ill pediatric patients: a single-center experience. J Health Sci Med. 2025;8(2):249-253.

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