JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Flow-mediated dilatation deficiency of the brachial artery and increased carotid intimal thickness in non-alcoholic fatty liver disease
Abstract
Aims: This study aimed to evaluate endothelial dysfunction and vascular changes in non-alcoholic fatty liver disease (NAFLD) patients by measuring carotid intima-media thickness (C-IMT) and flow-mediated dilation (FMD).
Methods: This prospective observational cohort study included 51 biopsy-proven NAFLD patients and 21 healthy controls. Endothelial function was assessed using high-resolution ultrasonography to measure brachial artery FMD and C-IMT. Patients with hepatotoxic drug use, significant alcohol consumption, or other liver diseases were excluded. Demographic data, body-mass index (BMI), and waist circumference were recorded. Statistical analyses were conducted using SPSS, with significance set at p<0.05.
Results: NAFLD patients showed significantly higher BMI, waist circumference, and diastolic blood pressure compared to controls. The mean C-IMT was elevated in NAFLD patients (0.67±0.09 mm) compared to controls (0.52±0.11 mm; p<0.001), and FMD was significantly reduced in NAFLD patients (7.3±4.8%) compared to controls (16.5±7.1%; p<0.001). FMD and C-IMT values were lower in NASH cases than in simple steatosis. A significant negative correlation was observed between FMD and BMI, waist circumference, and C-IMT values.
Conclusion: NAFLD patients, particularly those with NASH, exhibit significant endothelial dysfunction characterized by reduced FMD and increased C-IMT, indicating early atherosclerosis. These findings suggest that endothelial dysfunction increases with progression of NAFLD. Early recognition of vascular changes in NAFLD patients could facilitate timely interventions to reduce cardiovascular risk and disease progression.

Keywords : Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, vascular, carotid intima, liver disease

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1. Oni ET, Agatston AS, Blaha MJ, et al. A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care? Atherosclerosis. 2013;230(2):258-267. doi:10.1016/j.atherosclerosis.2013.07.052
2. Pastori D, Loffredo L, Perri L, et al. Relation of nonalcoholic fatty liver disease and Framingham Risk Score to flow-mediated dilation in patients with cardiometabolic risk factors. Am J Cardiol. 2015;115(10):1402-1406. doi:10.1016/j.amjcard.2015.02.032
3. Cattazzo F, Lombardi R, Mantovani A, et al. Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension. Nutr Metab Cardiovasc Dis. 2022;32(12):2839-2847. doi:10.1016/j.numecd.2022.08.005
4. Chen Y, Xu M, Wang T, et al. Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease. Atherosclerosis. 2015;241(1):145-150. doi:10.1016/j.atherosclerosis.2015. 05.002
5. Velarde-Ruiz Velasco JA, Garc&iacute;a-Jim&eacute;nez ES, Garc&iacute;a-Zerme&ntilde;o KR, et al. Extrahepatic complications of non-alcoholic disease fatty liver R. Rev Gastroenterol Mex (Engl Ed). 2019;84(4):472-481. doi:10.1016/j.rgmx. 2019.05.004
6. Li N, Zhang GW, Zhang JR, et al. Non-alcoholic fatty liver disease is associated with progression of arterial stiffness. Nutr Metab Cardiovasc Dis. 2015;25(2):218-223. doi:10.1016/j.numecd.2014.10.002
7. Oni E, Budoff MJ, Zeb I, et al. Nonalcoholic fatty liver disease is associated with arterial distensibility and carotid intima-media thickness: (from the multi-ethnic study of atherosclerosis). Am J Cardiol. 2019;124(4):534-538. doi:10.1016/j.amjcard.2019.05.028
8. Zhu W, Deng CJ, Xuan LP, et al. Peripheral artery disease and risk of fibrosis deterioration in nonalcoholic fatty liver disease: a prospective investigation. Biomed Environ Sci. 2020;33(4):217-226. doi:10.3967/bes 2020.031
9. Taharboucht S, Guermaz R, Brouri M, Chibane A. Subclinical atherosclerosis and arterial stiffness in nonalcoholic fatty liver disease: a case-control study in Algerian population. J Med Vasc. 2021;46(3):129-138. doi:10.1016/j.jdmv.2021.03.008
10. Liu S, Wang J, Wu S, et al. The progression and regression of metabolic dysfunction-associated fatty liver disease are associated with the development of subclinical atherosclerosis: a prospective analysis. Metabolism. 2021;120:154779. doi:10.1016/j.metabol.2021.154779
11. Cicero AFG, Gitto S, Fogacci F, et al. Fatty liver index is associated to pulse wave velocity in healthy subjects: data from the Brisighella heart study. Eur J Intern Med. 2018;53:29-33. doi:10.1016/j.ejim.2018.03.010
Article available in :
Volume 8, Issue 3, 2025
Page : 371-374
https://doi.org/10.32322/jhsm.1628609
Article Information
Received : 04 Şub 2025
Accepted : 24 Mar 2025
Published : 30 May 2025
Corresponding Author :

Umut Özdamarlar: Department of Radiology, Pendik Medicalpark Hospital, İstanbul, Turkiye

[email protected]
Citation : Özdamarlar U, Çolak Y. Flow-mediated dilatation deficiency of the brachial artery and increased carotid intimal thickness in non-alcoholic fatty liver disease. J Health Sci Med. 2025;8(3):371-374.

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