JHSM
Journal of Health Sciences and Medicine

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Original Article
The sleep-muscle axis: how poor sleep quality predicts probable sarcopenia in the older adults
Abstract
Aims: Investigate whether there is a link between the quality of sleep and the likelihood of developing sarcopenia in older adults.
Methods: Among the 498 patients over 65 who enrolled in the internal medicine geriatrics clinic between December 2024 and March 2025, 74 patients with poor sleep quality (group 1) and 110 patients with good sleep quality (group 2) were included in the study. The remaining 314 patients were excluded from the study. Demographic characteristics, body measurements, comprehensive geriatric assessments, potential sarcopenia assessments, and Pittsburgh sleep quality measurements were conducted.
Results: The average age of group 1, consisting of a total of 74 people, is 73.5±5.1 years, and the average age of group 2, consisting of 110 people, is 71.6±5.2 years. A statistically significant difference was detected between the groups in terms of average age distribution (p=0.03). The average body-mass index (BMI) value of group 1 patients was statistically significantly lower than that of group 2 patients (p=0.038). When the comprehensive geriatric evaluation was compared between the groups, the rate of possible sarcopenia was 81 percent in group 1 and 17 percent in group 2 (p<0.034).
Conclusion: Findings suggest a potential link between sleep quality and probable sarcopenia in older adults.

Keywords : Sleep quality, sarcopenia, older adults

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1. GBD 2019 Demographics Collaborators. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1160-1203. doi:10.1016/S0140-6736(20)30977-6
2. Gong J, Wang G, Wang Y, et al. Nowcasting and forecasting the care needs of the older population in China: analysis of data from the China health and retirement longitudinal study (CHARLS). Lancet Public Health. 2022;7(12):e1005-e1013. doi:10.1016/S2468-2667(22)00203-1
3. Gooneratne NS, Vitiello MV. Sleep in older adults: normative changes, sleep disorders, and treatment options. Clin Geriatr Med. 2014;30(3):591-627. doi:10.1016/j.cger.2014.04.007
4. Neikrug AB, Ancoli-Israel S. Sleep disorders in the older adult-a mini-review. Gerontology. 2010;56(2):181-189. doi:10.1159/000236900
5. Medic G, Wille M, Hemels ME. Short- and long-term health consequences of sleep disruption. Nat Sci Sleep. 2017;9:151-161. doi:10. 2147/NSS.S134864
6. Baar MP, Perdiguero E, Mu&ntilde;oz-C&aacute;noves P, de Keizer PL. Musculoskeletal senescence: a moving target ready to be eliminated. Curr Opin Pharmacol. 2018;40:147-155. doi:10.1016/j.coph.2018.05.007
7. 7. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169
8. Beaudart C, Zaaria M, Pasleau F, Reginster JY, Bruy&egrave;re O. Health outcomes of sarcopenia: a systematic review and meta-analysis. PLoS One. 2017;12(1):e0169548. doi:10.1371/journal.pone.0169548
9. Yuan S, Larsson SC. Epidemiology of sarcopenia: prevalence, risk factors, and consequences. Metabolism. 2023;144:155533. doi:10.1016/j.metabol.2023.155533
10. Xia L, Zhao R, Wan Q, et al. Sarcopenia and adverse health-related outcomes: an umbrella review of meta-analyses of observational studies. Cancer Med. 2020;9(21):7964-7978. doi:10.1002/cam4.3428
11. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011;12(4):249-256. doi:10.1016/j.jamda.2011.01.003
12. Cho YJ, Lim YH, Yun JM, Yoon HJ, Park M. Sex- and age-specific effects of energy intake and physical activity on sarcopenia. Sci Rep. 2020;10(1): 9822. doi:10.1038/s41598-020-66249-6
13. Otsuka Y, Iidaka T, Horii C, et al. Dietary intake of vitamin E and fats associated with sarcopenia in community-dwelling older japanese people: a cross-sectional study from the fifth survey of the ROAD study. Nutrients. 2021;13(5):1730. doi:10.3390/nu13051730
14. Jike M, Itani O, Watanabe N, Buysse DJ, Kaneita Y. Long sleep duration and health outcomes: a systematic review, meta-analysis and meta-regression. Sleep Med Rev. 2018;39:25-36. doi:10.1016/j.smrv.2017.06.011
15. Itani O, Jike M, Watanabe N, Kaneita Y. Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression. Sleep Med. 2017;32:246-256. doi:10.1016/j.sleep.2016.08.006
16. Li M, Wang N, Dupre ME. Association between the self-reported duration and quality of sleep and cognitive function among middle-aged and older adults in China. J Affect Disord. 2022;304:20-27. doi:10.1016/j.jad.2022.02.039
17. Fu L, Yu X, Zhang W, et al. The relationship between sleep duration, falls, and muscle mass: a cohort study in an elderly Chinese population. Rejuvenation Res. 2019;22(5):390-398. doi:10.1089/rej.2018.2102
18. Pana A, Sourtzi P, Kalokairinou A, Pastroudis A, Chatzopoulos ST, Velonaki VS. Association between muscle strength and sleep quality and duration among middle-aged and older adults: a systematic review. Eur Geriatr Med. 2021;12(1):27-44. doi:10.1007/s41999-020-00399-8
19. Rubio-Arias J&Aacute;, Rodr&iacute;guez-Fern&aacute;ndez R, Andreu L, Mart&iacute;nez-Aranda LM, Mart&iacute;nez-Rodriguez A, Ramos-Campo DJ. Effect of sleep quality on the prevalence of sarcopenia in older adults: a systematic review with meta-analysis. J Clin Med. 2019;8(12):2156. doi:10.3390/jcm8122156
20. Dattilo M, Antunes HK, Medeiros A, et al. Paradoxical sleep deprivation induces muscle atrophy. Muscle Nerve. 2012;45(3):431-433. doi:10.1002/mus.22322
21. Morrison M, Halson SL, Weakley J, Hawley JA. Sleep, circadian biology and skeletal muscle interactions: implications for metabolic health. Sleep Med Rev. 2022;66:101700. doi:10.1016/j.smrv.2022.101700
22. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179-186.
23. Arik G, Varan HD, Yavuz BB, et al. Validation of Katz Index of independence in activities of daily living in Turkish older adults. Arch Gerontol Geriatr. 2015;61(3):344-350. doi:10.1016/j.archger.2015.08.019
24. Sarikaya D, Halil M, Kuyumcu ME, et al. Mini nutritional assessment test long and short form are valid screening tools in Turkish older adults. Arch Gerontol Geriatr. 2015;61(1):56-60. doi:10.1016/j.archger.2015.04. 006
25. Mid&atilde;o L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018;78:213-220. doi:10. 1016/j.archger.2018.06.018
26. Rockwood K, Theou O. Using the Clinical Frailty Scale in allocating scarce health care resources. Can Geriatr J. 2020;23(3):210-215. doi:10. 5770/cgj.23.463
27. &Ouml;zs&uuml;rekci C, Balcı C, Kızılarslanoğlu MC, et al. An important problem in an aging country: identifying the frailty via 9 Point Clinical Frailty Scale. Acta Clin Belg. 2020;75(3):200-204. doi:10.1080/17843286.2019.1597457
28. Buysse DJ, Reynolds CF 3<sup>rd</sup>, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213. doi:10.1016/0165-1781 (89)90047-4
29. Watson NF, Badr MS, Belenky G, et al. Recommended amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep. 2015;38(6):843-844. doi:10.5665/sleep.4716
30. Strong K, Noor A, Aponte J, et al. Monitoring the status of selected health related sustainable development goals: methods and projections to 2030. Glob Health Action. 2020;13(1):1846903. doi:10.1080/16549716.2020.184 6903
31. Ismail Z, Ahmad WIW, Hamjah SH, Astina IK. The impact of population ageing: a review. Iran J Public Health. 2021;50(12):2451-2460. doi:10.18502/ijph.v50i12.7927
32. Ancoli-Israel S, Alessi C. Sleep and aging. Am J Geriatr Psychiatry. 2005; 13(5):341-343. doi:10.1176/appi.ajgp.13.5.341
33. Chaput JP, Dutil C, Sampasa-Kanyinga H. Sleeping hours: what is the ideal number and how does age impact this? Nat Sci Sleep. 2018;10:421-430. doi:10.2147/NSS.S163071
34. Helbig AK, D&ouml;ring A, Heier M, et al. Association between sleep disturbances and falls among the elderly: results from the German cooperative health research in the region of Augsburg-age study. Sleep Med. 2013;14(12):1356-1363. doi:10.1016/j.sleep.2013.09.004
35. Chien MY, Wang LY, Chen HC. The relationship of sleep duration with obesity and sarcopenia in community-dwelling older adults. Gerontology. 2015;61(5):399-406. doi:10.1159/000371847
36. Reid KF, Fielding RA. Skeletal muscle power: a critical determinant of physical functioning in older adults. Exerc Sport Sci Rev. 2012;40(1):4-12. doi:10.1097/JES.0b013e31823b5f13
37. Cruz-Jentoft AJ, Landi F, Schneider SM, et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International sarcopenia initiative (EWGSOP and IWGS). Age Ageing. 2014;43(6):748-759. doi:10.1093/ageing/afu115
38. Rodrigues F, Monteiro AM, Forte P, Morou&ccedil;o P. Effects of muscle strength, agility, and fear of falling on risk of falling in older adults. Int J Environ Res Public Health. 2023;20(6):4945. doi:10.3390/ijerph20064945
39. Chen LK, Woo J, Assantachai P, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300-307.e2. doi:10.1016/j.jamda.2019.12.012
40. Dodds R, Sayer AA. Sarcopenia and frailty: new challenges for clinical practice. Clin Med (Lond). 2016;16(5):455-458. doi:10.7861/clinmedicine.16-5-455
41. Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol. 2018;14(9): 513-537. doi:10.1038/s41574-018-0062-9
42. Grandner MA, Valencia DY, Seixas AA, et al. Development and initial validation of the assessment of sleep environment (ASE): describing and quantifying the impact of subjective environmental factors on sleep. Int J Environ Res Public Health. 2022;19(20):13599. doi:10.3390/ijerph 192013599
43. Miller MA, Howarth NE. Sleep and cardiovascular disease. Emerg Top Life Sci. 2023;7(5):457-466. doi:10.1042/ETLS20230111
44. Lavoie CJ, Zeidler MR, Martin JL. Sleep and aging. Sleep Sci Pract. 2018; 2:1-8. doi:10.1186/s41606-018-0021-3 </ol> </div> <p>
Article available in :
Volume 8, Issue 3, 2025
Page : 456-460
https://doi.org/10.32322/jhsm.1655166
Article Information
Received : 10 Mar 2025
Accepted : 05 May 2025
Published : 30 May 2025
Corresponding Author :

Zeynep Şahiner: Department of Geriatrics, Ankara Bilkent City Hospital, Ankara, Turkiye

[email protected]
Citation : Şahiner Z, Dikmeer Altuntaş A. The sleep-muscle axis: how poor sleep quality predicts probable sarcopenia in the older adults. J Health Sci Med. 2025;8(3):456-460.

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