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Journal of Health Sciences and Medicine

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Original Article
Sentinel lymph node detection using blue dye in patients with early stage cervical cancer: a pilot study
Abstract
Aims: This study aimed to determine the feasibility of sentinel lymph node (SLN) detection using lymphatic mapping with intraoperative isosulfan blue dye application in patients with earlystage invasive cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy.
Methods: From June 2009 to December 2010, 16 patients undergoing radical hysterectomy for early-stage cervical cancer (stage IA1, IB1) were offered lymph node mapping for identification of the SLN. The SLN mapping was done after intracervical isosulphane blue injection preoperatively. All patients underwent SLN identification via laparotomy followed by a complete pelvic and paraaortic lymph node disection and radical hysterectomy.
Results: The median age of the patients was 47 years (range: 36-68 years). The histological types identified included squamous cell carcinoma (12 cases), adenosquamous carcinoma (3 cases), and adenocarcinoma (1 case). The FIGO staging for the patients revealed Ia1 in 5 cases and Ib1 in 11 cases. A total of 417 lymph nodes (minimum 12, maximum 51), including SLNs, were removed from 16 patients. A total of 8 SLNs were identified in 5 patients: 1 in 3 patients, 2 in 1 patient, and 3 in 1 patient. All SLNs were unilateral. The technical failure rate of the procedure, defined as the inability to identify an SLN, was 68.8% (11/16), and the total SLN detection rate was 31.2% (5/16). Immunohistochemical examinations found no metastases in any of the SLNs. Ultrastaging also did not identify micrometastasis in any of the SLNs. Additionally, there were no metastases detected in the non- SLN s of patients who did not exhibit metastasis in the SLNs. Consequently, the false-negative rate could not be determined.
Conclusion: According to our preliminary study, although SLN mapping with blue dye is a low-cost, accessible, and easy-to perform method, it has a low detection rate of SLN.

Keywords : Cervical cancer, sentinel lymph node, lymphatic metastasis

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Article available in :
Volume 9, Issue 1, 2026
Page : 8-13
https://doi.org/10.32322/jhsm.1782201
Article Information
Received : 11 Eyl 2025
Accepted : 03 Kas 2025
Published : 05 Oca 2026
Corresponding Author :

Sevda Baş: Department of Obstetrics and Gynecology, Adana City Training and Research Hospital, University of Health Science, Adana, Turkey

[email protected]
Citation : Baş S, Karateke A. Sentinel lymph node detection using blue dye in patients with early stage cervical cancer: a pilot study. J Health Sci Med. 2026;9(1):8-13. doi:10.32322/jhsm.1782201

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