JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

eISSN: 2636-8579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
The relationship of prophylactically applied cervical cerclage with systemic inflamamatory parameters; its effect on cerclage success
Abstract
Aims: This study investigates the relationship between systemic inflammatory biomarkers-Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Pan-Immune Inflammation Value (PIV)-and pregnancy outcomes following prophylactic cervical cerclage. Methods: A retrospective analysis was conducted on 60 pregnant women who underwent prophylactic McDonald cerclage between November 2022 and September 2024. Patients were divided into two groups based on whether they delivered at term (?37 weeks) or preterm (

Keywords : Cervical cerclage, prophylactic cerclage, inflammatory biomarkers

Download Article


1. ACOG practice bulletin no.142: cerclage for the management of cervical insufficiency. Obstet Gynecol. 2014;123(2 Pt 1):372-379. doi:10. 1097/01.AOG.0000443276.68274.cc
2. Frey HA, Klebanoff MA. The epidemiology, etiology, and costs of preterm birth. Semin Fetal Neonatal Med. 2016;21(2):68-73. doi:10.1016/j.siny.2015.12.011
3. Practice bulletin no. 130: prediction and prevention of preterm birth. Obstet Gynecol. 2012;120(4):964-973. doi:10.1097/AOG.0b013e3182723b1b
4. Gonzales SK, Adair CD, Torres C, et al. Robotic-assisted laparoscopic abdominal cerclage placement during pregnancy. J Minim Invasive Gynecol. 2018;25(5):832-835. doi:10.1016/j.jmig.2017.12.014
5. Başbuğ A, Bayrak M, Doğan O, Ellibeş Kaya A, Goynumer G. McDonald versus modified shirodkar rescue cerclage in women with prolapsed fetal membranes. J Matern Fetal Neonatal Med. 2020;33(7):1075-1079. doi:10.1080/14767058.2018.1514378
6. Issah A, Diacci R, Williams KP, et al. McDonald versus shirodkar cerclage technique in women requiring a prophylactic cerclage: a systematic review and meta-analysis protocol. Syst Rev. 2021;10(1):130. doi:10.1186/s13643-021-01679-5
7. Namouz S, Porat S, Okun N, Windrim R, Farine D. Emergency cerclage: literature review. Obstet Gynecol Surv. 2013;68(5):379-388. doi:10.1097/OGX.0b013e31828737c7
8. Brown R, Gagnon R, Delisle MF. Maternal fetal medicine committee. Cervical insufficiency and cervical cerclage. J Obstet Gynaecol Can. 2013;35(12):1115-1127. doi:10.1016/S1701-2163(15)30764-7
9. Jung EY, Park KH, Lee SY, Ryu A, Joo JK, Park JW. Predicting outcomes of emergency cerclage in women with cervical insufficiency using inflammatory markers in maternal blood and amniotic fluid. Int J Gynaecol Obstet. 2016;132(2):165-169. doi:10.1016/j.ijgo.2015.07.011
10. Son GH, You YA, Kwon EJ, Lee KY, Kim YJ. Comparative analysis of midtrimester amniotic fluid cytokine levels to predict spontaneous very pre-term birth in patients with cervical insufficiency. Am J Reprod Immunol. 2016;75(2):155-161. doi:10.1111/aji.12451
11. Aguin E, Aguin T, Cordoba M, et al. Amniotic fluid inflammation with negative culture and outcome after cervical cerclage. J Matern Fetal Neonatal Med. 2012;25(10):1990-1994. doi: 10.3109/14767058.2012.667177
12. Lee KY, Jun HA, Kim HB, Kang SW. Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. Am J Obstet Gynecol. 2004;191(3):784-789. doi:10.1016/j.ajog.2004.04.019
13. Park JC, Kim DJ, Kwak-Kim J. Upregulated amniotic fluid cytokines and chemokines in emergency cerclage with protruding membranes. Am J Reprod Immunol. 2011;66(4):310-319. doi:10.1111/j.1600-0897.2011.0099 1.x
14. Wang J, Zhou D, Dai Z, Li X. Association between systemic immune-inflammation index and diabetic depression. Clin Interv Aging. 2021;16: 97-105. doi:10.2147/CIA.S285000
15. Zhang F, Niu M, Wang L, et al. Systemic-immune-inflammation index as a promising biomarker for predicting perioperative ischemic stroke in older patients who underwent non-cardiac surgery. Front Aging Neurosci. 2022;14:865244. doi:10.3389/fnagi.2022.865244
16. Tian T, Lu J, Zhao W, et al. Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population. Cancer Med. 2022;11(12):2482-2491. doi: 10.1002/cam4.4606
17. Lin Y, Fang J, Ni R, et al. Dynamic change of novel systemic inflammation markers to predict maternal-neonatal prognosis after cervical cerclage. J Inflamm Res. 2023;16:1745-1756. doi: 10.2147/JIR.S410211
18. Huang L, Wang W, Wang Y, et al. Effectiveness and pregnancy outcomes of ultrasound-indicated and physical examination-indicated cervical cerclage: a retrospective study from a single centre. BMC Pregnancy Childbirth. 2024;24(1):467. doi:10.1186/s12884-024-06659-w
19. Fang J, Lin Y, Chen Z, Lin Y, Pan M. The Association of inflammatory markers with maternal-neonatal outcome after cervical cerclage. J Inflamm Res. 2023;16:245-255. doi:10.2147/JIR.S393666
20. Gülücü S, Gümüşburun N. The role of inflammatory markers in the evaluation of cerclage success: inflammatory markers in the cerclage success. Chronicles of Precision Medical Researchers. 2022;3(3):174-179.
Article available in :
Volume 9, Issue 1, 2026
Page : 60-64
https://doi.org/10.32322/jhsm.1744795
Article Information
Received : 21 Tem 2025
Accepted : 19 Kas 2025
Published : 05 Oca 2026
Corresponding Author :

Sait Erbey: Department of Obstetrics and Gynaecology, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Erbey S, Sapmaz MA, Polat M, Kından A, Çelen Ş. The relationship of prophylactically applied cervical cerclage with systemic inflamamatory parameters; its effect on cerclage success. J Health Sci Med. 2026;9(1):60-64. doi:10.32322/jhsm.1744795

Read: 178
Download : 164
Cited: 1
_Footer