JHSM

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Post-stroke physical rehabilitation and neuroplasticity: a bibliometric analysis (2000-2024)
Aims: This study aims to systematically analyze the global scientific literature on neuroplasticity in post-stroke rehabilitation to uncover major research themes, thematic evolution, and collaboration networks over the last two decades.
Methods: A bibliometric analysis was conducted using data retrieved from the Web of Science Core Collection database, covering the period from January 2000 to December 2024. A total of 1.484 publications met the inclusion criteria. VOS viewer software was utilized to perform co-occurrence, co-authorship, co-citation, and bibliographic coupling analyses to visualize the intellectual structure and trends of the field.
Results: A total of 1,484 publications were analyzed, revealing a sharp acceleration in scientific output since 2020, with a CAGR of 13.5% and a peak of 368 articles in 2023. Keyword mapping demonstrated a distinct thematic shift from foundational biological processes (2016-2018) toward advanced technological interventions like BCI, robotics, and virtual reality (2020-2022). The United States, China, and Italy emerged as the primary hubs of global productivity. Finally, co-citation and bibliographic coupling analyses delineate an integrated intellectual landscape sustained by four primary research axes: motor cortex plasticity, clinical protocols, non-invasive neuromodulation, and neuroimaging-based language recovery.
Conclusion: Post-stroke neuroplasticity research has transformed into a highly dynamic and interdisciplinary field. The findings indicate a significant shift from basic biological research towards personalized and technology-assisted rehabilitation strategies. Future trends suggest an increasing integration of neuroengineering and multimodal therapies to optimize functional recovery.


1. Feigin VL, Stark BA, Johnson CO, et al. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol. 2021;20:795-820. doi:10.1016/S1474-4422 (21)00252-0
2. Kleim JA, Jones TA. Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. J Speech Lang Hear Res. 2008;51(1):S225-S239. doi:10. 1044/1092-4388(2008/018)
3. Nudo RJ. Recovery after brain injury: mechanisms and principles. Front Hum Neurosci. 2013;7:887. doi:10.3389/fnhum.2013.00887
4. Buma F, Kwakkel G, Ramsey N. Understanding upper limb recovery after stroke. Restor Neurol Neurosci. 2013;31(6):707-722. doi:10.3233/RN N-130332
5. Ang KK, Guan C, Phua KS, et al. Brain-computer interface-based robotic end effector system for wrist and hand rehabilitation: results of a three-armed randomized controlled trial for chronic stroke. Front Neuroeng. 2014;7:30. doi:10.3389/fneng.2014.00030
6. Mehrholz J, Thomas S, Werner C, Kugler J, Pohl M, Elsner B. Electromechanical-assisted training for walking after stroke. Cochrane Database Syst Rev. 2017;5(5):CD006185. doi:10.1002/14651858.CD0061 85.pub4
7. Li C, Tu S, Xu S, et al. Research hotspots and frontiers of transcranial direct current stimulation in stroke: a bibliometric analysis. Brain Sci. 2022;13(1):15. doi:10.3390/brainsci13010015
8. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523-538. doi:10.1007/s11192-009-0146-3
9. Chen C. Science mapping: a systematic review of the literature. J Data Inf Sci. 2017;2:1-40.
10. Tang S, Gao M, Cheng X, Ji L. Scientometric analysis of post-stroke depression research based on CiteSpace. Medicine (Baltimore). 2023;102( 18):e33633. doi:10.1097/MD.0000000000033633
11. Xu F, Bai L, Dai Z, Cheng H. Research hotspots and trends in post-stroke dysphagia: a bibliometric analysis. Front Neurosci. 2023;17:1275748. doi: 10.3389/fnins.2023.1275748
12. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: an overview and guidelines. J Bus Res. 2021;133:285-296. doi:10.1016/j.jbusres.2021.04.070
13. Ward NS. Restoring brain function after stroke-bridging the gap between animals and humans. Nat Rev Neurol. 2017;13(4):244-255. doi: 10.1038/nrneurol.2017.34
14. Krakauer JW, Carmichael ST, Corbett D, Wittenberg GF. Getting neurorehabilitation right: what can be learned from animal models?. Neurorehabil Neural Repair. 2012;26(8):923-931. doi:10.1177/1545968312 440745
15. Grefkes C, Ward NS. Cortical reorganization after stroke: how much and how functional?. Neuroscientist. 2014;20(1):56-70. doi:10.1177/10738584 13491147
16. Heiberg AV, Simonsen SA, Schytz HW, Iversen HK. Cortical hemodynamic response during cognitive Stroop test in acute stroke patients assessed by fNIRS. NeuroRehabilitation. 2023;52(2):199-217. doi:10.3233/NRE-220171
17. Laver KE, Lange B, George S, Deutsch JE, Saposnik G, Crotty M. Virtual reality for stroke rehabilitation. Cochrane Database Syst Rev. 2017;11(11): CD008349. doi:10.1002/14651858.CD008349.pub4
18. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009;10(12):861-872. doi:10.1038/nrn2 735
19. Langhorne P, Bernhardt J, Kwakkel G. Stroke rehabilitation. Lancet. 2011;377(9778):1693-1702. doi:10.1016/S0140-6736(11)60325-5
20. Biasiucci A, Leeb R, Iturrate I, et al. Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke. Nat Commun. 2018;9(1):2421. doi:10.1038/s41467-018-04673-z
21. Pazzaglia M, Molinari M. The embodiment of assistive devices-from wheelchair to exoskeleton. Phys Life Rev. 2016;16:163-175. doi:10.1016/j.p lrev.2015.11.006
22. Daly JJ, Wolpaw JR. Brain-computer interfaces in neurological rehabilitation. Lancet Neurol. 2008;7(11):1032-1043. doi:10.1016/S1474-4 422(08)70223-0
23. Kilgard MP, Rennaker RL, Alexander J, Dawson J. Vagus nerve stimulation paired with tactile training improved sensory function in a chronic stroke patient. NeuroRehabilitation. 2018;42(2):159-165. doi:10. 3233/NRE-172273
24. Stagg CJ, Johansen-Berg H. Studying the effects of transcranial direct-current stimulation in stroke recovery using magnetic resonance imaging. Front Hum Neurosci. 2013;7:857. doi:10.3389/fnhum.2013.00 857
25. Stinear CM, Lang CE, Zeiler S, Byblow WD. Advances and challenges in stroke rehabilitation. Lancet Neurol. 2020;19(4):348-360. doi:10.1016/S 1474-4422(19)30415-6
26. Hu J, Zou J, Wan Y, et al. Rehabilitation of motor function after stroke: a bibliometric analysis of global research from 2004 to 2022. Front Aging Neurosci. 2022;14:1024163. doi:10.3389/fnagi.2022.1024163
Volume 9, Issue 1, 2026
Page : 213-220
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