JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Total knee arthroplasty in alkaptonuric ochronosis: a case report
Abstract
A 65-year-old male patient presented to our hospital with complaints of bilateral knee pain and functional limitation. Without a preoperative diagnosis of alkaptonuria, the patient was evaluated as grade IV osteoarthrosis according to the classical Kellgren Lawrence classification, and total knee arthroplasty was performed. The diagnosis of alkaptonuria was established in the postoperative period by examination of biopsy materials obtained during surgery. Alkaptonuria is generally diagnosed late due to its slow progression. In young patients presenting with large joint arthritis, ochronosis should be suspected as a possible diagnosis. In advanced ochronotic arthrosis, successful outcomes can be achieved with total joint replacement therapy.

Keywords : Alkaptonuria, homogentisic acid oxidase, osteoarthrosis, knee replacement, arthroplasty

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Article available in :
Volume 9, Issue 1, 2026
Page : 253-255
https://doi.org/10.32322/jhsm.1786236
Article Information
Received : 18 Eyl 2025
Accepted : 03 Ara 2025
Published : 05 Oca 2026
Corresponding Author :

Bedrettin Akar: Deparmant of Orthopedics and Traumatology, Sakarya Yenikent State Hospital, Sakarya, Turkey

[email protected]
Citation : Akar B, Öztürkmen Y, Balioğlu MB, Erkek M, Harmanşa S. Total knee arthroplasty in alkaptonuric ochronosis: a case report. J Health Sci Med. 2026;9(1):253-255. doi:10.32322/jhsm.1786236

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