JHSM

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis
Aims: Acute appendicitis (AA) is a common surgical emergency with a heterogeneous clinical and pathological spectrum. Given their established roles in immune modulation, inflammation, and host-pathogen interactions, ABO blood group antigens have been investigated in various infectious and inflammatory diseases. In this study, we aimed to investigate the association between blood groups and the clinical course of acute appendicitis. Methods: This retrospective study data from patients who underwent appendectomy at our center were analyzed. Patients were classified into normal (n=42), uncomplicated (n=970), and complicated (n=213) appendicitis groups based on histopathological findings. Demographic data, ABO blood groups, histopathological findings, preoperative laboratory parameters, and length of hospital stay were evaluated and statistical analyses were performed. Results: No significant differences were observed in ABO blood group distribution among histopathological subgroups (p>0.05). In multivariate analysis, age and C-reactive protein remained independent predictors of complicated appendicitis (p


1. Bayrak S, Tatar C, Cakar E, et al. Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly. North Clin Istanb. 2019;6(3):293-301. doi:10.14744/nci.2019.93457
2. Kalaycı T, Balcı S. Factors affecting morbidity in appendectomy: a single center experience. Turk J Colorectal Dis. 2022;32(1):41-47. doi:10.4274/tjcd.galenos.2021.2021-3-2
3. Vaos G, Zavras N. Update on the diagnosis and treatment of acute appendicitis. J Clin Med. 2024;13(23):7343. doi:10.3390/jcm13237343
4. Schildberg CW, Reissig K, Hunger R, et al. Diagnostic, therapy and complications in acute appendicitis of 19,749 cases based on routine data: a retrospective multicenter observational study. J Clin Med. 2022;11(15):4495. doi:10.3390/jcm11154495
5. Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15(1):27. doi:10.1186/s13017-020-00306-3
6. De Almeida Leite RM, Seo DJ, Gomez-Eslava B, et al. Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis. JAMA Surg. 2022;157(9):828-834. doi:10.1001/jamasurg.2022.2937
7. Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018;320(12):1259-1265. doi:10.1001/jama.2018.13201
8. Gaitanidis A, Kaafarani HM, Christensen MA, et al. Association between NEDD4L variation and the genetic risk of acute appendicitis: a multi-institutional genome-wide association study. JAMA Surg. 2021;156(10):917-923. doi:10.1001/jamasurg.2021.3303
9. Landsteiner K. Agglutination phenomena in normal human blood. Wien Klin Wochenschr. 1901;14:1132-1134.
10. Daniels G, Bromilow I. Essential Guide to Blood Groups. Chichester, UK: Wiley-Blackwell; 2013.
11. Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016;8(6):517-535. doi:10.1002/wsbm.1355
12. Daniels G. Human Blood Groups. 2nd ed. Oxford, UK: Blackwell Science; 2002.
13. Cartron JP, Colin Y. Structural and functional diversity of blood group antigens. Transfus Clin Biol. 2001;8(3):163-199. doi:10.1016/S1246-7820(01)00142-2
14. Abegaz SB. Human ABO blood groups and their associations with different diseases. Biomed Res Int. 2021:6629060. doi:10.1155/2021/6629060
15. Keser-Şahin HH, Avcı F, Kulhan M, et al. Investigation of the effect of ABO blood types on the prognosis of endometrioid-type endometrial cancer. Cir Cir. 2024;92(6):808-813. doi:10.24875/ciru.24000061
16. Basta M, Radovanovic Z, Radojicic C. On the association between appendicitis and ABO blood groups. Transfusion. 1986;26(3):305-306. doi:10.1046/j.1537-2995.1986.26386209400.x
17. Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Rev. 2015;28(3):801-870. doi:10.1128/cmr.00109-14
18. Anstee DJ. The relationship between blood groups and disease. Blood. 2010;115(23):4635-4643. doi:10.1182/blood-2010-01-261859
19. Ravn V, Dabelsteen E. Tissue distribution of histo-blood group antigens. APMIS. 2000;108(1):1-28. doi:10.1034/j.1600-0463.2000.d01-1.x
20. Salduz Z, Çetin G, Karatoprak C, et al. ABO and Rh blood group distribution in İstanbul province (Turkey). Istanbul Med J. 2015;16(3): 103-107.
21. Kader Ç, Yolcu S, Doğan B, Pınarbaşlı M, İlanbey B, Erbay A. ABO and Rh blood groups distribution in Yozgat city, Turkey. J Clin Exp Invest. 2014;5(2):169-172.
22. Gutiérrez-Valencia M, Leache L, Librero J, et al. ABO blood group and risk of COVID-19 infection and complications: a systematic review and meta-analysis. Transfusion. 2021;62(2):493-503. doi:10.1111/trf.16748
23. Butler EA, Parikh R, Grandi SM, et al. ABO and Rh blood groups and risk of infection: systematic review and meta-analysis. BMC Infect Dis. 2023;23(1):797. doi:10.1186/s12879-023-08792-x
24. Blohs M, Robinson PJ, Kompella P, et al. Acute appendicitis manifests as two microbiome state types with oral pathogens influencing severity. Gut Microbes. 2023;15(1):2145845. doi:10.1080/19490976.2022.2145845
25. Aiyoshi T, Kakihara T, Watanabe E, et al. Unique microbial profiles and severity-associated alterations in the peritoneal fluid of children with acute appendicitis. J Infect Chemother. 2025;31(8):102761. doi:10.1016/j.jiac.2025.102761
26. Sagor MS, Islam T, Tamanna NT, et al. The functional landscape of the appendix microbiome under conditions of health and disease. Gut Pathog. 2025;17(1):38. doi:10.1186/s13099-025-00696-2
27. Bandyopadhyay A, Sarkar D, Das A, et al. Intersections of ABO blood group, secretor status, and the gut microbiome: implications for disease susceptibility and therapeutics. Arch Microbiol. 2025;207(11):296. doi:10.1007/s00203-025-04515-9
28. Jajosky RP, Wu SC, Zheng L, et al. ABO blood group antigens and differential glycan expression: perspective on the evolution of common human enzyme deficiencies. iScience. 2023;26(1):105798. doi:10.1016/j.isci.2022.105798
29. Zietz M, Zucker J, Tatonetti NP. Associations between blood type and COVID-19 infection, intubation, and death. Nat Commun. 2020;11(1): 5761. doi:10.1038/s41467-020-19623-x
30. Reilly JP, Meyer NJ, Shashaty MGS, et al. ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis. Chest. 2014;145(4):753-761. doi:10.1378/chest.13-1962
31. Özozan ÖV, Vural V. High C-reactive protein level as a predictor for appendiceal perforation. Ulus Travma Acil Cerrahi Derg. 2020;26(1):63-66. doi:10.14744/tjtes.2019.14799
32. Zengin A, Bağ YM, Öğüt MZ, et al. The role of C-reactive protein/albumin ratio and prognostic nutritional index in the diagnosis of complicated acute appendicitis. Turk J Surg. 2024;40(1):54-60. doi:10. 47717/turkjsurg.2024.6301
33. Zhao X, Yang J, Li J. The predictive value of the C-reactive protein/albumin ratio in adult patients with complicated appendicitis. J Lab Med. 2023.
34. Turkes GF, Unsal A, Bulus H. Predictive value of immature granulocyte in the diagnosis of acute complicated appendicitis. PLoS One. 2022; 17(12):e0279316. doi:10.1371/journal.pone.0279316
35. Korkut M, Bedel C, Selvi F. Are immature granulocytes and derivatives early predictors of acute appendicitis and acute complicated appendicitis in adults? Formos J Surg. 2020;53(4):123-127. doi:10.4103/fjs.fjs_111_19
36. Tullavardhana T, Sanguanlosit S, Chartkitchareon A. Role of platelet indices as a biomarker for the diagnosis of acute appendicitis and as a predictor of complicated appendicitis: a meta-analysis. Ann Med Surg (Lond). 2021;66:102448. doi:10.1016/j.amsu.2021.102448
37. Gwin JC, Rangnekar N, Murray GP, et al. O blood type is not associated with worse coagulopathy or outcome in exsanguinating trauma. Am J Surg. 2024;234:117-121. doi:10.1016/j.amjsurg.2024.03.021
Volume 9, Issue 3, 2026
Page : 658-663
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