JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

eISSN: 2636-8579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
Factors associated with length of hospital stay in patients with non-biliary acute pancreatitis
Abstract
Aims: This study aimed to investigate the factors associated with prolonged hospital stays in patients diagnosed with non-biliary acute pancreatitis. Methods: The medical records of 76 patients diagnosed with non-biliary acute pancreatitis at the Internal Medicine Clinic, Afyonkarahisar University of Health Sciences Hospital, between January 1, 2020, and December 31, 2023, were retrospectively analyzed. The diagnosis of acute pancreatitis was based on the presence of two of the following three criteria: (i) Sudden-onset, severe, upper abdominal pain characteristic of acute pancreatitis that may radiate to the back, (ii) A significant increase in serum lipase or amylase levels (three times the upper limit of normal), and (iii) Radiological findings consistent with acute pancreatitis. Biliary pancreatitis was excluded based on the absence of stones on ultrasound and/or MRCP and the normal appearance of the common bile duct. Therefore, in our study, hospital stays of 8 days or longer were defined as prolonged hospital stays. Patients were divided into two groups based on their length of hospital stay. Those who stayed in the hospital for 8 days or longer were included in the long-stay group, while those who stayed for less than 8 days were included in the short-stay group. The following data were recorded: age, sex, history of diabetes mellitus, hypertension, and coronary artery disease, alcohol use, and use of angiotensin-converting enzyme inhibitors/ARBs, calcium channel blockers dipeptidyl peptidase-4 inhibitors, and diuretics. In addition, patients’ Bedside Index for Severity in Acute Pancreatitis (BISAP) score and Ranson score at admission (0-h) and at 48-h were evaluated. Laboratory findings included white blood cell count, neutrophil and lymphocyte counts, neutrophil-to-lymphocyte ratio, hemoglobin, hematocrit, C-reactive protein, albumin, and triglyceride levels. Variables with p-values less than 0.2 were included in the binary logistic regression analysis. Due to multicollinearity with the BISAP and Ranson scores, the age and white blood cell count variables were not included in the multivariate analysis model. p65 years. The mean length of hospital stay was 6.62±2.53 days, and 32.9% of the patients were hospitalized for 8 days or longer. Comorbidities were present in 53.9% of the patients, with diabetes mellitus, hypertension, and coronary artery disease being the most common. No significant association was found between laboratory parameters and prolonged hospital stay (all p>0.05). No significant differences were observed between groups regarding sex, comorbidities, medication use, and alcohol consumption (all p>0.05). Age >65 years was found to be significantly associated with prolonged hospital stay (p=0.018). In univariate analysis, age >65 years (p=0.011; OR: 3.72; 95% CI: 1.355-10.215) and white blood cell count (p=0.049; OR: 1.11; 95% CI: 1.0-1.247) were found to be associated with prolonged hospital stay. However, due to multicollinearity, age and white blood cell count were excluded from the multivariate model. BISAP and 48-h Ranson scores were higher in the long-stay group (p

Keywords : Acute pancreatitis, BISAP score, ranson score, morbidity, prolonged hospital stay

Download Article


1. Ignatavicius P, Gulla A, Cernauskis K, Barauskas G, Dambrauskas Z. How severe is moderately severe acute pancreatitis? Clinical validation of revised 2012 Atlanta Classification. World J Gastroenterol. 2017; 23(43):7785-7790. doi:10.3748/wjg.v23.i43.7785
2. Pitchumoni CS, Patel NM, Shah P. Factors influencing mortality in acute pancreatitis: can we alter them? J Clin Gastroenterol. 2005;39(9):798-814. doi:10.1097/01.mcg.0000177257.87939.00
3. PanWessex Study Group; Wessex Surgical Trainee Research Collaborative; Mirnezami A, et al. Population-based observational study of acute pancreatitis in southern England. Ann R Coll Surg Engl. 2019;101(7):487-494. doi:10.1308/rcsann.2019.0055
4. Sarı A, Ulu MS, Kazan S, Tunca O, Kazan ED. Comparison of monocyte/HDL ratio in routine hemodialysis and peritoneal dialysis patients. Dicle Tıp Derg. 2020;47:139-147. doi:10.5798/dicletip.706097
5. Hosmer DW Jr, Lemeshow S, Sturdivant RX. The multiple logistic regression model. In: Applied Logistic Regression. 3rd ed. Wiley; 2013:35-47. doi:10.1002/9781118548387.ch2
6. Peery AF, Crockett SD, Barritt AS, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149(7):1731-1741.e3. doi:10.1053/j.gastro.2015.08.045
7. Tamer A, Yaylacı S, Demirsoy H, et al. Akut pankreatitli olgularımızın retrospektif değerlendirilmesi. Sakarya Tıp Derg. 2011;1(1):17-21. doi:10. 5505/sakaryamj.2011.39974
8. Carvalho JR, Fernandes SR, Santos P, Moura CM, Antunes T, Velosa J. Acute pancreatitis in the elderly: a cause for increased concern? Eur J Gastroenterol Hepatol. 2018;30(3):337-341. doi:10.1097/MEG.000000000 0001028
9. Sarı A, Güngören H, Kazan ED, et al. The effects of monocyte/high-density lipoprotein ratio on hospital stay in patients with mild acute pancreatitis. Health Sci Q. 2023;3(2):69-74. doi:10.26900/hsq.1886
10. Koziel D, Gluszek-Osuch M, Suliga E, Zak M, Gluszek S. Elderly persons with acute pancreatitis: specifics of the clinical course of the disease. Clin Interv Aging. 2019;14:33-41. doi:10.2147/CIA.S188520
11. Yadav D, Lowenfels AB. Trends in the epidemiology of the first attack of acute pancreatitis: a systematic review. Pancreas. 2006;33(4):323-330. doi:10.1097/01.mpa.0000236733.31617.52
12. Uomo G, Pezzilli R, Gabbrielli A, et al. Diagnostic assessment and outcome of acute pancreatitis in Italy: results of a prospective multicentre study. ProInf-AISP: Progetto informatizzato pancreatite acuta, Associazione Italiana Studio Pancreas, phase II. Dig Liver Dis. 2007;39(9):829-837. doi:10.1016/j.dld.2007.05.009
13. Samokhvalov AV, Rehm J, Roerecke M. Alcohol consumption as a risk factor for acute and chronic pancreatitis: a systematic review and a series of meta-analyses. EBioMedicine. 2015;2(12):1996-2002. doi:10.1016/j.ebiom.2015.11.023
14. Farkas N, Hanak L, Miko A, et al. A multicenter, international cohort analysis of 1435 cases to support clinical trial design in acute pancreatitis. Front Physiol. 2019;10:1092. doi:10.3389/fphys.2019.01092
15. Yao J, Lv G. Association between red cell distribution width and acute pancreatitis: a cross-sectional study. BMJ Open. 2014;4(8):e004721. doi: 10.1136/bmjopen-2013-004721
16. Schutte K, Malfertheiner P. Markers for predicting severity and progression of acute pancreatitis. Best Pract Res Clin Gastroenterol. 2008;22(1):75-90. doi:10.1016/j.bpg.2007.10.013
17. Dervenis C, Johnson CD, Bassi C, et al. Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. Int J Pancreatol. 1999;25(3):195-210. doi:10.1007/BF02925 968
18. Eckart A, Struja T, Kutz A, et al. Relationship of nutritional status, inflammation, and serum albumin levels during acute illness: a prospective study. Am J Med. 2020;133(6):713-722.e7. doi:10.1016/j.amjmed.2019.10.031
19. Amri F, Rahaoui M, Aissaoui H, et al. Is serum albumin a pivotal biomarker in anticipating acute pancreatitis outcomes? BMC Gastroenterol. 2024;24(1):234. doi:10.1186/s12876-024-03314-8
20. Wang Q, Wang G, Qiu Z, He X, Liu C. Elevated serum triglycerides in the prognostic assessment of acute pancreatitis: a systematic review and meta-analysis of observational studies. J Clin Gastroenterol. 2017;51(7): 586-593. doi:10.1097/MCG.0000000000000846
21. Kim BG, Noh MH, Ryu CH, et al. A comparison of the BISAP score and serum procalcitonin for predicting the severity of acute pancreatitis. Korean J Intern Med. 2013;28(3):322-329. doi:10.3904/kjim. 2013.28.3.322
22. Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut. 2008;57(12):1698-1703. doi:10.1136/gut.2008.152702
23. Algin A, Ozdemir S, Afacan MA, et al. The role of combined C-reactive protein and albumin indices in predicting prolonged hospital stay in acute pancreatitis: a prospective observational study. Medeni Med J. 2025;40(2):72-79. doi:10.4274/MMJ.galenos.2025.73848
Article available in :
Volume 9, Issue 3, 2026
Page : 679-685
https://doi.org/10.32322/jhsm.1886354
Article Information
Received : 10 Şub 2026
Accepted : 08 May 2026
Published : 19 May 2026
Corresponding Author :

Abdullah Avlağı: Department of Internal Medicine, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkiye

[email protected]
Citation : Avlağı A, Sağlam O, Sarı A, Bozkurt E, Ceyhan HŞ. Factors associated with length of hospital stay in patients with non-biliary acute pancreatitis. J Health Sci Med. 2026;9(3):679-685. doi:10.32322/jhsm.1886354

Read: 205
Download : 90
Cited: 0
_Footer