JHSM
Journal of Health Sciences and Medicine

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Original Article
Safety, treatment adherence, and patient satisfaction in major ozone autohemotherapy: a single-center retrospective study
Abstract
Aims: This study evaluated adverse events reported during and after major ozone autohemotherapy (MAHT), treatment adherence, and patient satisfaction, with particular emphasis on difficult venous access (DVA) in relation to adherence. Methods: This single-center, non-interventional, retrospective descriptive survey study included 240 patients aged ?18 years who underwent MAHT between January 2024 and November 2025. Approximately 100 ml of venous blood was used per session. Ozone concentration ranged from 15 to 35 µg/ml, and sessions were scheduled twice weekly. Results: Mean age was 53.1±12.4 years, and 68.8% of participants were female. The completion rate of planned sessions was 65.0% (156/240). Adverse events during treatment occurred in 11.3% of patients (27/240; 95% CI 7.8-15.9), and 88.9% were related to venous access or procedural factors. DVA was observed in 7.1% of the total sample (17/240) and in 63.0% of those reporting procedural adverse effects (17/27). Age ?60 years was associated with higher odds of DVA (OR=3.79; 95% CI 1.38-10.41). Post-treatment adverse effects occurred in 3.8% of patients (9/240; 95% CI 2.0-7.0). Procedural adverse events were associated with treatment non-completion (RR=2.63; p

Keywords : Ozone therapeutic use, patient safety, treatment adherence, patient satisfaction, peripheral venous catheterizations

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Article available in :
Volume 9, Issue 3, 2026
Page : 774-779
https://doi.org/10.32322/jhsm.1905576
Article Information
Received : 12 Mar 2026
Accepted : 24 Nis 2026
Published : 19 May 2026
Corresponding Author :

Ekrem Yılmaz: Department of Traditional and Complementary Medicine, Institute of Health Sciences, Lokman Hekim University, Ankara, Turkiye

[email protected]
Citation : Yılmaz E, Çevik C. Safety, treatment adherence, and patient satisfaction in major ozone autohemotherapy: a single-center retrospective study. J Health Sci Med. 2026;9(3):774-779. doi:10.32322/jhsm.1905576

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