JHSM
Journal of Health Sciences and Medicine

Journal of Health Sciences and Medicine (JHSM) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Preoperative HbA1c and vitamin D levels in endometrial carcinoma: correlation with grade and lymphovascular space invasion
Abstract
Aims: This study aimed to evaluate preoperative HbA1c and serum 25-hydroxyvitamin D levels in patients with endometrial carcinoma and to investigate their associations with tumor grade and lymphovascular space invasion (LVSI). Methods: This retrospective study included 81 patients with histologically confirmed endometrial carcinoma and 30 control patients diagnosed with endometrial hyperplasia who underwent hysterectomy. Patients were categorized into four groups: grade 1-2 LVSI-negative, grade 1-2 LVSI-positive, grade 3 tumors, and controls. Preoperative glucose, HbA1c, and vitamin D levels were retrieved from medical records. Group comparisons were performed using Welch’s ANOVA with Games-Howell post hoc testing. Multivariate analysis of covariance (MANCOVA) was conducted adjusting for age and body-mass index. Results: Patients with endometrial carcinoma were significantly older and had higher BMI, glucose, and HbA1c levels, along with lower vitamin D concentrations compared with controls (all p

Keywords : Endometrial carcinoma, HbA1c, vitamin D, tumor grade, lymphovascular space invasion

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Article available in :
Volume 9, Issue 3, 2026
Page : 806-811
https://doi.org/10.32322/jhsm.1917062
Article Information
Received : 27 Mar 2026
Accepted : 24 Nis 2026
Published : 19 May 2026
Corresponding Author :

Figen Efe Çamili: Department of Obstetrics and Gynecology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkiye

[email protected]
Citation : Efe Çamili F, Nurdogan F, Şimşekoğlu Polat E, Afşar S, Güney G, Taşkın M. Preoperative HbA1c and vitamin D levels in endometrial carcinoma: correlation with grade and lymphovascular space invasion. J Health Sci Med. 2026;9(3):806-811. doi:10.32322/jhsm.1917062

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